Entity Address, City or Town
Entity Address, City or Town
Business Combination Upfront Consideration paid in Common Stock
The aggregate amount of consideration paid to former stockholders and optionholders in common stock, as part of a business combination, excluding purchase price adjustments.
Business combination upfront consideration paid in common stock
Schedule of Reconciliation of Income Tax Expense
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Net loss attributable to common stockholders
Net Income (Loss) Available to Common Stockholders, Basic
Income Tax Examination, Year under Examination
Income tax examination, year under examination
Fair Value Disclosures [Abstract]
Prime Medicine Inc
Prime Medicine Inc [Member]
Prime medicine Inc.
Earnings Per Share [Abstract]
Level 1
Fair Value, Inputs, Level 1 [Member]
Liabilities, Fair Value Adjustment
Change in fair value
Schedule of Accrued Liabilities [Table Text Block]
Schedule of Accrued Expenses and Other Current Liabilities
Business Combination Contingent Consideration Liability Expected Achievement Year
The year in which achievement is expected to be attained for contingent consideration liability milestones.
Milestone liabilities projected year of achievement
Manufacturing Facility
Manufacturing Facility [Member]
2025
Finance Lease, Liability, to be Paid, Year Three
Federal
Domestic Tax Authority [Member]
Stock Issued During Period, Value, New Issues
Value of common stock shares issued
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs
Research and Development Costs
Research and Development Expense, Policy [Policy Text Block]
Financing activities
Net Cash Provided by (Used in) Financing Activities [Abstract]
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Non-cash contribution of intellectual property to Orbital Therapeutics Inc.
Contribution of Property
License Agreement Terms [Member]
License Agreement Terms
Fair Value Measurement
Fair Value Measurement [Domain]
Sana Biotechnology.
Sana Biotechnology
Amendment Flag
Amendment Flag
Aggregate fair value of restricted shares vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
The amount receivable on the one-year anniversary of the signing date of a collaboration agreement.
Collaboration Agreement First Anniversary Amount Receivable
Collaboration agreement first anniversary amount receivable
Property and equipment additions in accounts payable and accrued expenses
Capital Expenditures Incurred but Not yet Paid
Maximum number of shares for future issuance
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Number of shares available for future issuance
The fair value of shares received as an upfront payment as part of license agreement.
Upfront Payment Fair Value Shares Received
Upfront payment fair value shares received
Subsequent Event Type
Subsequent Event Type [Domain]
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Reimbursed Costs [Member]
Reimbursed Costs
Litigation Case [Domain]
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Net operating loss carryforward amount with limit on use
Net Operating Loss Carryforward Amount with Limit on Use
Net operating loss carryforward amount with limit on use.
At-The-Market
ATM Offering
At-The-Market .
At The Market [Member]
Less: imputed interest
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Net Loss Per Share
Earnings Per Share, Policy [Policy Text Block]
Finance lease liability payments interest percentage
Finance Lease Liability Payments Interest Percentage
The interest rate on finance leases.
Carrying value of equity method investment
Equity Method Investments
Pfizer Inc [Member]
Pfizer Inc
Statement [Table]
Statement [Table]
Long-term lease liability
Operating Lease, Liability, Noncurrent
2023
Finance Lease, Liability, to be Paid, Year One
Payment of interest
Finance Lease, Interest Expense
Change in fair value of contingent consideration liabilities
Change in fair value of contingent consideration liabilities
Change In Fair Value Of Contingent Consideration Liabilities
Amount of increase (decrease) in the fair value of contingent consideration recognized in the income statement.
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Operating cash flows used for operating leases
Operating Lease, Payments
Purchase of common stock under ESPP, Shares
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Number of operating segment
Number of Operating Segments
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Business Acquisition
Business Acquisition [Axis]
Number of shares reserved for future issuance
Common Stock, Capital Shares Reserved for Future Issuance
Auditor Firm ID
Unvested as of December 31, 2022
Unvested as of December 31, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Bio Palette Patent
Bio Palette Patent [Member]
Bio Palette Patent.
Business Combination Disclosure [Text Block]
Guide Acquisition
Income Tax Authority
Income Tax Authority [Domain]
Product and Service
Product and Service [Axis]
Uncertain tax positions
Liability for Uncertainty in Income Taxes, Current
Employee Stock [Member]
ESPP
Financing milestone liabilities
Increase Decrease In Financing Milestone Liabilities
Increase (decrease) in financing milestone liabilities.
Business Combination, Contingent Consideration, Liability, Total
Business Combination, Contingent Consideration, Liability
Contingent consideration liability
Employee compensation and related benefits
Employee-related Liabilities, Current
Employee-related Liabilities, Current, Total
Lessee, Operating Leases [Text Block]
Leases
Noncash or Part Noncash Acquisition, Description
Merger agreement description
Unvested Stock Options
Stock Options
Outstanding Options to Purchase Common Stock
Weighted-average remaining lease term (years)
Operating Lease, Weighted Average Remaining Lease Term
Total liabilities and stockholders' equity
Liabilities and Equity
Tax Period [Axis]
ROU asset
Deferred Tax Liabilities, Leasing Arrangements
Tenant improvement allowance
Payments for (Proceeds from) Tenant Allowance
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Harvard Institute.
Harvard Institute [Member]
Harvard Institute
Plan Name
Plan Name [Domain]
Area of Rented Space
The amount of area rented under an operating lease, in square feet.
Square feet of office and laboratory space
Equity Method Investments [Policy Text Block]
Corporate Equity Securities
Available For Sale Debt Securities and Equity Securities FV-Ni
Marketable securities held, Fair Value
Amount of investment in debt and equity securities measured at fair value (available-for-sale).
Scientific Founders
Scientific Founders [Member]
Scientific founders.
Denominator:
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Change in Accounting Principle, Accounting Standards Update, Adopted
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Derivative liabilities
Derivative Liability, Current
Discount for Lack of Marketability
Measurement Input, Discount Rate [Member]
Discount Rate
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Income Statement [Abstract]
Operating lease, number of renewal options
Number Of Operating Lease Renewal Options
Number of operating lease renewal options.
Non United States
Non-US [Member]
Reverse stock split
Stockholders' Equity, Reverse Stock Split
Reverse stock split
Orbital
Orbital
Orbital Therapeutics, Inc [Member]
Orbital Therapeutics, Inc.
Nature of the Business and Basis of Presentation
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Proceeds from issuances of stock under ESPP
Proceeds from Stock Plans
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Noncurrent Liabilities, Other
Other liabilities assumed
Current portion of equipment financing liability
Finance Lease, Liability, Current
Sale of Stock
Sale of Stock [Domain]
Aggregate intrinsic value
Share Based Compensation Arrangement By Share Based Payment Award Aggregate Intrinsic Value [Abstract]
Share based compensation arrangement by share based payment award aggregate intrinsic value.
Total current liabilities
Liabilities, Current
Business Combinations Policy [Policy Text Block]
Contingent Consideration Liabilities
Purchase of common stock under ESPP
Stock Issued During Period, Value, Employee Stock Purchase Plan
Net operating loss carryforwards
Operating Loss Carryforwards
Operating Loss Carryforwards, Total
Nondeductible/ nontaxable permanent items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
2025
Lessee, Operating Lease, Liability, to be Paid, Year Three
Cash Acquired from Acquisition
Net cash acquired from Guide
Business Acquisition, Acquiree
Business Acquisition, Acquiree [Domain]
Recurring
Fair Value, Recurring [Member]
Additional success payment amount due.
Additional Success Payment Amount Due
Additional success payment amount due
Operating lease, termination month and year
Operating Lease Termination Month And Year
Operating lease, termination month and year.
Short-term lease costs
Short-Term Lease, Cost
Income Taxes
Income Tax, Policy [Policy Text Block]
Transaction price allocated to each performance obligations.
Transaction Price Allocated to Each Performance Obligations
Transaction price allocated to each of six performance obligations
Increase (Decrease) in Contract with Customer, Liability
Deferred revenue
Development Regulatory and Commercial Milestones Receivable
Development regulatory and commercial milestones receivable
The amount of milestones the Company may be eligible to receive.
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Other Assets
Other Noncurrent Assets [Member]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Assigned to company.
Assigned to Company [Member]
Assigned to Company
Exploitation Licenses
Exploitation Licenses [Member]
Exploitation licenses.
Weighted-average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Upfront fee paid
Payment Of Upfront Fee
Payment of upfront fee.
Investment, Name [Domain]
Revenue, Product and Service [Extensible List]
Revenue, Product and Service [Extensible Enumeration]
Entity Small Business
Entity Small Business
Total cash, cash equivalents, and restricted cash
Cash, cash equivalents and restricted cash—beginning of period
Cash, cash equivalents and restricted cash—end of period
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents
Office and Laboratory Space
Office And Laboratory Space [Member]
Office and laboratory space.
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Stock-Based Compensation
Compensation Related Costs, Policy [Policy Text Block]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Fair Value Measurement Inputs and Valuation Techniques [Table]
Goodwill and Intangible Assets, Intangible Assets, Policy [Policy Text Block]
Patent Costs
The automatic increase in the number of shares that may be issued under a share-based payment arrangement on the first day of each fiscal year, as a percentage of shares outstanding.
Share Based Compensation Arrangement By Share Based Payment Award Annual Increase Percentage
Annual percentage increase in shares authorized
The number of shares of common stock received as part of a collaboration agreement.
Common stock shares received at closing
Collaboration Common Shares Received
Collaboration agreement aggregate transaction price
Equity Method Investment, Quoted Market Value
Total current assets
Assets, Current
Property Plant And Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Revenue Program Performance Obligation Period
Revenue program performance obligation period
The period over which performance obligations are expected to be recognized.
Apellis and Pfizer
Apellis and Pfizer [Member]
Apellis and Pfizer.
Weighted - average common shares outstanding, basic
Weighted-average common shares outstanding, basic and diluted
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Financing obligations
Finance Lease, Liability
Finance Lease, Liability, Total
City Area Code
City Area Code
Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Forfeitures
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Share-Based Payment Arrangement [Abstract]
Total liabilities
Liabilities
Private Placement
Private Placement [Member]
Document Period End Date
Document Period End Date
Payment of equity offering costs
Payment of initial and follow-on public offering costs
Payments of Stock Issuance Costs
Lease Contractual Term
Lease Contractual Term [Domain]
Unvested Restricted Stock
Restricted Stock
Restricted Stock [Member]
Equity Method Investment
Equity Method Investments and Joint Ventures Disclosure [Text Block]
Collaboration Agreement Performance Obligation Revenue Recognized
The amount of revenue recognized during the period for satisfaction of performance obligations as part of a collaboration agreement.
Collaboration agreement performance obligation revenue recognized
Construction in Process
Construction in Progress [Member]
Stock options
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Weighted-average grant date fair value per share of stock options granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Operating lease, option to extend term
Lessee, Operating Lease, Renewal Term
Debt Securities, Available-for-Sale, Amortized Cost
Available-for-sale, Amortized Cost
Contract with Customer, Liability, Noncurrent
Long-term portion of deferred revenue
Statistical Measurement
Statistical Measurement [Axis]
Non Royalty Sublicense Fees Owed
Non-royalty sublicense fees owed
The amount of expense incurred for non-royalty sublicense fees owed to licensor.
Related Party
Related Party [Axis]
Total assets
Assets
Income from related party
Related Party Transaction, Other Revenues from Transactions with Related Party
Accounting Standards Update 2016-02 [Member]
ASU 2016-02
Contract with Customer, Asset, after Allowance for Credit Loss, Total
Contract with Customer, Asset, after Allowance for Credit Loss
Contract asset
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering, Shares
Stock Issued During Period, Shares, Conversion of Convertible Securities
Nonrefundable upfront payment receivable.
Nonrefundable upfront payment receivable
Gross proceeds from issuance of common stock.
Gross Proceeds From Issuance Of Common Stock
Gross proceeds from issuance of common stock
State
State and Local Jurisdiction [Member]
Performance-based Stock Options
Performance Based Stock Options [Member]
Performance-based stock options.
Success payment liability, term
Derivative, Term of Contract
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per common share attributable to common stockholders, diluted
Schedule of Potential Common Shares Excluded from Computation of Diluted Net Loss per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Beginning Balance
Beginning Balance
Ending Balance
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
The annual rent amount under a financing lease.
Finance Lease Annual Rent
Finance lease annual rent
Commencement of second phase of lease in January two thousand twenty one.
Commencement Of Second Phase Of Lease In January Two Thousand Twenty One [Member]
Second Phase of Lease in January 2021
Document Fiscal Period Focus
Document Fiscal Period Focus
Deferred Offering Costs
Equity issuance costs
Less: valuation allowance
Deferred Tax Assets, Valuation Allowance
Deferred Tax Assets, Valuation Allowance, Total
Preferred stock, $0.01 par value; 25,000,000 shares authorized, and no shares issued or outstanding at December 31, 2022 and December 31, 2021, respectively
Preferred Stock, Value, Issued
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
2027
Finance Lease, Liability, to be Paid, Year Five
Counterparty Name [Domain]
Operating Lease, Liability
Operating Lease, Liability, Total
Lease liability
Total operating lease liabilities
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Weighted-average grant date fair value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Property and equipment
Deferred Tax Liabilities, Property, Plant and Equipment
Statement of Financial Position [Abstract]
Entity File Number
Securities Act File Number
Scenario [Domain]
Total
Finance Lease, Liability, to be Paid
The percentage of annual taxable income to which net operating loss carryforwards are limited.
Net operating loss carryforward limit percentage
Net Operating Loss Carryforward Limit Percentage
Potential Milestone Payable In Form Of Common Stock
The amount of potential milestones payable in the form of common stock as part of a business combination.
Potential milestone payable in form of common stock
Statement of Cash Flows [Abstract]
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Thereafter
Sublease income
Sublease Income
Sublease income
Valuation Approach and Technique [Domain]
Including Two Thousand Seventeen Plan Shares [Member]
Including Two Thousand Seventeen Plan Shares [Member]
Including 2017 Plan Shares
Schedule of Success Payment Liability
Schedule Of Success Payment Liability Table [Text Block]
Tabular disclosure of the success payment liability arising from a licensing agreement.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Summary of significant accounting policies.
Geographical
Geographical [Domain]
Statistical Measurement
Statistical Measurement [Domain]
Broad Institute
Broad License Agreement [Member]
Broad license agreement.
Broad License Agreement
Statement of Stockholders' Equity [Abstract]
Sale of Stock
Sale of Stock [Axis]
Auditor Location
Class of Stock
Class of Stock [Domain]
Revenue from Contract with Customer [Policy Text Block]
Contract Balances
Legal Entity
Legal Entity [Axis]
Summary of Operating Lease Costs
Lease, Cost [Table Text Block]
Percentage of fully diluted equity interest
Equity Method Investment, Ownership Percentage
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Summary of significant accounting policies.
Change in fair value of derivative liabilities
Change In Fair Value Of Derivative Liabilities
Amount of increase (decrease) in the fair value of derivative liabilities.
Subsequent Events [Abstract]
Fair Value of Financial Instruments
Fair Value Disclosures [Text Block]
Payments to Acquire Equity Securities, FV-NI
Purchase of non-controlling equity investment
Success Payments.
Success Payments [Member]
Success Payments
Accounting Standards Update 2014-09 [Member]
ASC 606
Exercisable as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Proceeds from exercise of stock options
Proceeds from Stock Options Exercised
Proceeds from Issuance of Common Stock
Proceeds from issuance of common shares, net of underwriting discount and commissions
Summary Of Depreciation Expense Incurred Table Text Block
Tabular disclosure of depreciation expense related to physical assets used in the normal conduct of business and not intended for resale.
Summary of Depreciation Expense Incurred
Stock Options and Restricted Stock
Stock Options And Restricted Stock [Member]
stock options and restricted stock.
Research and development tax credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
Schedule of Property and Equipment
Property, Plant and Equipment [Table Text Block]
Business Combination, Contingent Consideration, Liability, Measurement Input
Contingent consideration liability measurement input
Concentrations of Credit Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Pfizer.
Pfizer [Member]
Pfizer
Antidilutive Securities
Antidilutive Securities [Axis]
Number of shares issued for upfront payment of acquisition.
Number Of Shares Issued For Upfront Payment Of Acquisition
Number of shares issued for upfront payment of acquisition
Accounting standard update 201701.
Accounting Standard Update 201701 [Member]
ASU 2017-01
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Preferred stock, par or stated value per share
Preferred Stock, Par or Stated Value Per Share
Contract with Customer, Liability, Current
Current portion of deferred revenue
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Available-for-sale, Gross Unrealized Gains
Lessee Lease Description [Line Items]
Lessee, Lease, Description [Line Items]
Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net
Total transaction price
Cash, cash equivalents, and marketable securities
Cash, Cash Equivalents, and Short-Term Investments
Cash, Cash Equivalents, and Short-term Investments, Total
Credit Facility [Domain]
Subsequent Events
Subsequent Events [Text Block]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Weighted - average common shares outstanding, diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Weighted-average common shares used in net loss per share attributable to common stockholders, diluted
Finite-Lived Intangible Assets, Major Class Name [Domain]
Credit Facility [Axis]
Unrecognized stock-based compensation expense, expected to vest
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering
Temporary Equity Conversion Of Redeemable Convertible Preferred Stock To Common Stock Upon Closing Of Initial Public Offering Value
The value of stock converted upon the conversion of convertible securities.
Corporate Notes
Corporate Debt Securities [Member]
Fair Value Disclosure Item Amounts [Default]
Portion at Fair Value Measurement [Member]
Portion at Fair Value Measurement [Member] [Default]
Computer Equipment
Computer Equipment [Member]
General and Administrative
General and Administrative Expense [Member]
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Common stock issuable upon conversion
Shares issued upon conversion of preferred stock
Convertible Preferred Stock, Shares Issued upon Conversion
Net Profits and Development and Commercialization Costs Percentage
Net profits as well as development and commercialization costs percentage
The percentage of net profits and development and commercialization costs assigned to the specified party.
Receipt of common stock in exchange for technology license
Receipt Of Common Stock In Exchange For Technology License
The value of common stock received in exchange for a technology license.
Success payments
Success Payments
The amount of success payments payable upon achievement of specified stock value targets.
Unrecognized compensation cost related to unvested stock options
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Issuance of common stock related to license agreement, Shares
Issuance Of Common Stock Shares Related To License Agreement
Number of shares issued during the period related to a license agreement.
Commercial Paper
Commercial Paper [Member]
Nature Of Business And Basis Of Presentation [Table]
Nature Of Business And Basis Of Presentation [Table]
Nature of the business and basis of presentation.
Current Fiscal Year End Date
Current Fiscal Year End Date
Percentage of exercise price per share of stock options on fair market value of common stock
Share Based Compensation Arrangement By Share Based Payment Award Percentage Of Exercise Price Per Share Of Stock Options On Fair Market Value Of Common Stock
The minimum exercise price per share of stock options, as a percentage of the fair market value of common stock on the date of grant.
Liability Class [Axis]
Marketable Securities, Realized Gain (Loss), Total
Marketable Securities, Realized Gain (Loss)
Realized gains or losses recognized on sale or maturity of marketable securities
Depreciation expense
Depreciation
Depreciation
Depreciation, Total
Financial Instruments
Financial Instruments [Domain]
Collaboration Agreement Upfront Payment Received
The amount of upfront payment received as part of a collaboration agreement.
Collaboration agreement upfront payment received
Obligation to Issue Common Stock Shares
The number of shares of stock the Collaborator is obligated to issue to the Company if the Company elects to extend the collaboration.
Obligation to issue common stock shares
Other assets
Other Assets, Noncurrent
Other Assets, Noncurrent, Total
Business combination transaction price.
Business Combination Transaction Price [Abstract]
Transaction price
Amortization of investment discount (premiums)
Investment Income, Net, Amortization of Discount and Premium
Investment Income, Net, Amortization of Discount and Premium, Total
Entity Address, Address Line One
Entity Address, Address Line One
Guarantees and Indemnifications
Guarantees, Indemnifications and Warranties Policies [Policy Text Block]
Collaboration Arrangement Extension Term
Collaboration arrangement extension term.
Collaboration arrangement extension term
Milestone payment paid
Payment Of Milestone Amount
Payment of milestone amount.
Fair value of equity instruments issued in connection with asset acquisition.
Fair Value Of Equity Instruments Issued In Connection With Asset Acquisition
Fair value of equity instruments issued in connection with asset acquisition
Document Annual Report
Document Annual Report
Schedule of Share-Based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block]
Schedule of Assumptions Used in Black-Scholes Option Valuation Model to Estimate Fair Value of Purchase Right Under ESPP
Apellis
Apellis Pharmaceuticals Inc [Member]
Apellis Pharmaceuticals, Inc.
Apellis Pharmaceuticals, Inc
Finite-Lived Intangible Assets by Major Class [Axis]
Supplemental disclosure of cash flow information:
Supplemental Cash Flow Information [Abstract]
Deferred tax assets:
Components of Deferred Tax Assets [Abstract]
Marketable Securities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Number of founder shareholders
Number Of Founder Shareholders
Number of founder shareholders.
Contingent Consideration Type [Domain]
Restricted cash
Restricted Cash, Noncurrent
Jeffries LLC Amended Sales Agreement [Member]
Jeffries LLC amended sales agreement.
Jeffries LLC Amended Sales Agreement
Provision for income taxes
Income tax expense
Income Tax Expense (Benefit)
Income Tax Expense (Benefit), Total
Increase (Decrease) in Operating Lease Liability
Operating lease liabilities
Process development and manufacturing costs
Accrued Process Development And Manufacturing Costs
Carrying value as of the balance sheet date of obligations incurred through that date and payable for process development and manufacturing costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Open Tax Year
Open tax year
Non-royalty sublicense fees paid
Non Royalty Sublicense Fees Paid
The amount paid during the period for non-royalty sublicense fees.
Income Taxes
Income Tax Disclosure [Text Block]
Preferred stock, shares issued
Preferred Stock, Shares Issued
Preferred Stock, Shares Issued, Total
Balance Sheet Location
Balance Sheet Location [Domain]
Contingent consideration liabilities.
Contingent Consideration Liabilities [Member]
Contingent Consideration Liabilities
Other Accrued Liabilities, Current
Other
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment
Payments to Acquire Property, Plant, and Equipment, Total
Revenue, Remaining Performance Obligation, Amount
Allocated transaction price to each of six performance obligations
Income Tax Disclosure [Abstract]
Equity Issuance Costs
Equity Issuance Costs Policies Policy [Text Block]
Disclosure of accounting policy for equity issuance costs.
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering, Shares
Temporary Equity Conversion Of Redeemable Convertible Preferred Stock To Common Stock Upon Closing Of Initial Public Offering Shares
The number of shares converted upon the conversion of convertible securities.
Upon participation election.
Upon Participation Election [Member]
Upon Participation Election
Change in operating lease right-of-use assets
Change In Operating Lease Right Of Use Assets
Amount of increase (decrease) in operating lease right-of-use assets.
Employees, Officers, Board of Directors and Consultants
Employees Officers Board Of Directors And Consultants [Member]
Employees, officers, board of directors and consultants
Number of common stock issued
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs, Shares
Shares issued and sold
Plus: residual values
Direct Financing Lease, Residual Value of Leased Asset
Earliest Tax Year [Member]
Earliest Tax Year
Carrying Amount
Reported Value Measurement [Member]
Assets
Assets, Fair Value Disclosure [Abstract]
The amount of fee per additional option right.
Additional Fee Per Additional Option Right
Additional fee per additional option right
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Conversion of redeemable convertible preferred stock to common stock upon closing of the initial public offering
Conversion of Stock, Amount Converted
Auditor Name
2026
Finance Lease, Liability, to be Paid, Year Four
Operating lease, commencement month and year
Operating Lease Commencement Month And Year
Operating lease, commencement month and year.
Forfeitures
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Other long-term liabilities
Increase (Decrease) in Other Noncurrent Liabilities
Loss from operations
Operating Income (Loss)
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Number of shares issued
Operating lease, option to extend
Lessee, Operating Lease, Option to Extend
Related Party
Related Party [Domain]
Share Based Compensation Arrangement By Share Based Payment Award Offering Period Start Date
The commencement date of the first offering period of a share based payment plan, in YYYY-MM-DD format.
Common stock, offering period, start date
Redeemable convertible preferred stock, Beginning Balance
Redeemable convertible preferred stock, Ending Balance
Temporary Equity, Carrying Amount, Attributable to Parent
Redeemable convertible preferred stock (See Note 11, Redeemable convertible preferred stock)
Scenario [Axis]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Research and Development in Process
Research and development expense
In-process research and development charge
Professional fees
Accrued Professional Fees, Current
Common stock, voting rights
Common Stock, Voting Rights
Entity Filer Category
Entity Filer Category
Schedule of Equity Method Investments [Line Items]
Available For Sale Debt Securities and Equity Securities FV-Ni Accumulated Gross Unrealized Loss Before Taxes
Marketable securities held, Gross Unrealized Losses
Amount, before tax, of unrealized loss on investment in debt and equity securities measured at fair value (available-for-sale).
Debt Securities, Available-for-sale, Maturity Period
Describes the period of time in which investments will reach maturity.
Contractual maturity dates of investments
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent, Total
Other comprehensive income (loss)
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment, Total
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment
Property and equipment
Total operating expenses
Operating Expenses
Fair Value by Liability Class [Domain]
Equity issuance costs in accounts payable and accrued expenses
Equity Issuance Costs In Accounts Payable And Accrued Expenses
Equity issuance costs in accounts payable and accrued expenses.
Entity Current Reporting Status
Entity Current Reporting Status
Vesting of restricted common stock
Stock Issued During Period, Value, Restricted Stock Award, Gross
From 2017 plan shares.
From 2017 Plan Shares
From Two Thousand Seventeen Plan Shares [Member]
Asset Class
Asset Class [Domain]
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Exercisable as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Equity shares held
Equity shares held
Equity Shares Held
The number of shares of equity securities held by the Company.
Preferred and Common Stock
Stockholders' Equity Note Disclosure [Text Block]
Business Combinations [Abstract]
Beginning Balance
Ending Balance
Stockholders' Equity Attributable to Parent
Total stockholders' equity
Stock Issuance Costs
Costs incurred in a stock issuance transaction.
Stock issuance costs
In Process Research and Development [Member]
In-Process Research and Development
Accumulated Other Comprehensive Income (Loss)
Accumulated Other Comprehensive (Loss) Income
AOCI Attributable to Parent [Member]
Asset Class
Asset Class [Axis]
Reconciliation of net loss to net loss attributable to common stockholders:
Reconciliation Of Net Gain Loss To Net Loss Attributable To Common Stockholders [Abstract]
Reconciliation of net loss to net gain (loss) attributable to common stockholders.
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Schedule of Available-for-Sale Securities Reconciliation [Table Text Block]
Summary of Marketable Securities Held
Entity Tax Identification Number
Entity Tax Identification Number
Income Statement Location
Income Statement Location [Axis]
Forfeited
Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Common stock, $0.01 par value; 250,000,000 shares authorized, 71,277,339 and 68,581,251 issued, and 71,277,339 and 68,389,425 outstanding at December 31, 2022 and December 31, 2021, respectively
Milestone payment value of stock issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Common stock, value
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Equipment
Equipment [Member]
Equity Components
Equity Components [Axis]
Change in fair value of derivative liabilities
Derivative, Gain (Loss) on Derivative, Net
Derivative, Gain (Loss) on Derivative, Net, Total
Change in fair value of derivative liabilities
Series B Redeemable Convertible Preferred Stock
Series B Redeemable Convertible Preferred Stock [Member]
Series B redeemable convertible preferred stock.
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease), Total
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease)
Change in fair value
Lab Equipment
Lab Equipment [Member]
Lab equipment.
Unrealized gain (loss) on marketable securities
Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent, Total
Other Comprehensive Income (Loss), Available-for-Sale Securities Adjustment, Net of Tax, Portion Attributable to Parent
Accounting Standards Update [Domain]
Leases [Abstract]
Contract with Customer, Liability, Total
Contract with Customer, Liability
Deferred revenue liability
Variable Interest Entities
Consolidation, Variable Interest Entity, Policy [Policy Text Block]
The amount received as upfront payment under a license agreement.
License Agreement Upfront Payment Received
License agreement upfront payment received
Collaboration Receivable Current
Amounts due as part of a collaboration agreement, due within 1 year (or 1 business cycle).
Collaboration receivable
Amount of costs capitalized for research and development as of the balance sheet date.
Capitalized research and development costs
Capitalized R&D Costs
Equity Method Investments and Joint Ventures [Abstract]
Business Acquisition, Date of Acquisition Agreement
Business Acquisition, merger agreement date
Entity Emerging Growth Company
Entity Emerging Growth Company
Related Party Transaction
Related Party Transaction [Axis]
Common stock received.
Common Stock Received
Schedule of Business Acquisitions, by Acquisition [Table]
Operating expenses:
Operating Expenses [Abstract]
Sublease Commencement Month and Year
The month and year in which a sublease will commence.
Sublease, commencement month and year
Volatility of Market Participants
Expected Volatility
Measurement Input, Price Volatility [Member]
Verve Therapeutics, Inc.
Verve Therapeutics Inc [Member]
Verve Therapeutics, Inc.
Commercial milestone payments or royalties due
Commercial Milestone Payments Or Royalties Due
The amount of commercial milestone payments or royalties due.
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale
Maturities of marketable securities
Revenue Recognition
Revenue [Policy Text Block]
Schedule Of Stock By Class [Table]
Schedule of Stock by Class [Table]
Letter of Credit [Member]
Letter of Credit
Expected term (in years)
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Non Cash Research And Development License Expense
Non-cash research and development license expense, net
Amount of noncash research and development expense for licensing agreements.
Jeffries LLC Sales Agreement [Member]
Jeffries LLC sales agreement.
Jeffries LLC Sales Agreement
Success Payments, valuation multiples
Success Payments Valuation Multiples
The valuation multiple applied to the initial weighted average of the specified class of stock, used to determine success payment targets.
Upfront Revenue Recognized
The amount of upfront revenue recognized.
Upfront revenue recognized
Guide Therapeutics, Inc.
Guide Therapeutics Incorporated [Member]
Guide Therapeutics, Incorporated.
Lessee, Operating Lease, Liability, to be Paid [Abstract]
Accrued Research Costs
Carrying value as of the balance sheet date of obligations incurred through that date and payable for research costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Research costs
Debt Securities, Available-for-Sale [Table]
Investment, Name [Axis]
Entity Voluntary Filers
Entity Voluntary Filers
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum
Earn-out payment period.
Earnout Payment Period
Earn-out payment period
Defined contribution plan name.
Defined Contribution Plan Name
Defined contribution plan name
Retirement Benefits [Abstract]
Derivative liabilities
Deferred Tax Assets, Derivative Instruments
Document Transition Report
Document Transition Report
Total Assets
Assets, Fair Value Disclosure
Total assets
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Prepaid Expense and Other Assets
Prepaid expenses and other assets
Issued
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
The fair value of common stock issued to satisfy a success payment obligation.
Fair Value Of Common Stock Issued To Settle Success Payment Liability
Fair value of common stock issued to settle success payment liability
Nonoperating Income (Expense)
Total other income (expense)
Accrued Expenses and Other Current Liabilities
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Collaboration agreement first anniversary payment received
Collaboration Agreement First Anniversary Payment Received
The amount received as payment for the first anniversary of a collaboration agreement.
Depreciation, Depletion and Amortization, Total
Depreciation, Depletion and Amortization
Depreciation and amortization
Impairment of long-lived assets
Impairment, Long-Lived Asset, Held-for-Use
Impairment, Long-Lived Asset, Held-for-Use, Total
Non-Statutory Options
Non Statutory Options [Member]
Non-statutory options.
The amount of expense recognized during the period for achievement of a milestone.
Milestone Expense
Milestone expense
Amount before allocation of valuation allowances of deferred tax asset attributable to capitalized research and development.
Capitalized Research
Deferred Tax Assets, Capitalized Research
Collaboration and License Agreements
Collaborative Arrangement Disclosure [Text Block]
Exercised
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted-average exercise price of stock options
The sale price of assets sold to a leasing company for leaseback.
Assets sold for leaseback
Success payment liability measurement input
Derivative Liability, Measurement Input
Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Accumulated other comprehensive (loss) income
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Tax Period [Domain]
Marketable Securities
Marketable Securities, Policy [Policy Text Block]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table]
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Option Pricing Model
Valuation Technique, Option Pricing Model [Member]
Weighted average remaining contractual life (years)
Share Based Compensation Arrangement By Share Based Payment Award Weighted Average Remaining Contractual Life [Abstract]
Share based compensation arrangement by share based payment award weighted average remaining contractual life.
Current portion of lease liability
Operating Lease, Liability, Current
Adjustments to Additional Paid in Capital, Increase in Carrying Amount of Redeemable Preferred Stock
Accretion of redeemable convertible preferred stock to redemption value
Schedule of Fair Value of Financial Assets and Liabilities
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Additional Paid-in Capital
Additional Paid-in Capital [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Issuance of common stock for research and development licenses
Stock Issued
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash and Equivalents
Cash acquired
License agreement description
Agreement description
Collaborative Arrangement, Nature and Purpose
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Schedule of Variables Included in Calculation of Estimated Fair Value
Entity Registrant Name
Entity Registrant Name
Total liabilities
Liabilities, Fair Value Disclosure
Total liabilities
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Net Loss per Share Attributable to Common Stockholders
Earnings Per Share [Text Block]
Schedule of Assumptions Used in Black-Scholes Option-Pricing Model for Stock Options Granted
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Common stock issued.
Common Stock Issued
Related Party Transaction, Amounts of Transaction
Payments received from (made to) related parties
Class of Stock
Class of Stock [Axis]
Government Securities
US Government Agencies Debt Securities [Member]
Lessee Lease Description [Table]
Lessee, Lease, Description [Table]
Stock-based compensation expense
Share-Based Payment Arrangement, Noncash Expense
Share-based Payment Arrangement, Noncash Expense, Total
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Award Type
Award Type [Domain]
Statement [Line Items]
Statement [Line Items]
Common stock offering price discount rate at start of the offering period
Share-Based Compensation Arrangement by Share-Based Payment Award, Discount from Market Price, Offering Date
Percentage of common stock purchase price lower of the fair market value
Liabilities
Liabilities, Fair Value Disclosure [Abstract]
Title of 12(b) Security
Title of 12(b) Security
Lease liability
Deferred Tax Assets Leasing Arrangements
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from lease liabilities.
Accounts payable
Increase (Decrease) in Accounts Payable
Increase (Decrease) in Accounts Payable, Total
Derivative Liability [Abstract]
Common Stock
Common Stock [Member]
Net proceeds from sale of common stock
Sale of Stock, Consideration Received on Transaction
Shares issued and sold
Available For Sale Debt Securities and Equity Securities FV-Ni Accumulated Gross Unrealized Gain Before Taxes
Marketable securities held, Gross Unrealized Gains
Amount, before tax, of unrealized gain on investment in debt and equity securities measured at fair value (available-for-sale).
Expiration period
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Cash, Cash Equivalents, and Restricted Cash
Operating activities
Net Cash Provided by (Used in) Operating Activities [Abstract]
Equity Component
Equity Component [Domain]
Stock Issued During Period Value Success Payment Liability
Value of stock issued to satisfy success payment obligation.
Issuance of common stock for success payment liability
Payments to Acquire Debt Securities, Available-for-Sale
Purchases of marketable securities
Accretion of redeemable convertible preferred stock to redemption value
Temporary Equity, Accretion to Redemption Value
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Revenue from Contract with Customer, Excluding Assessed Tax
License and collaboration revenue
License revenue
Net loss before income taxes
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Less: amounts representing interest at 8.76%
Less: amounts representing interest at 8.76%
Finance Lease, Liability, Undiscounted Excess Amount
Reconciliation of Cash, Cash Equivalents, and Restricted Cash
Schedule of Cash and Cash Equivalents [Table Text Block]
Entity Address, State or Province
Entity Address, State or Province
Purchases from related party
Related Party Transaction, Purchases from Related Party
2026
Lessee, Operating Lease, Liability, to be Paid, Year Four
Geographical
Geographical [Axis]
Founder Shareholders
Founder Shareholders [Member]
Founder Shareholders.
Net change in cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Document Type
Document Type
Interest Paid, Excluding Capitalized Interest, Operating Activities
Cash paid for interest
Contingent consideration of product liabilities.
Contingent Consideration Of Product Liabilities [Member]
Contingent Consideration of Product Liabilities
Product Milestones
United States
UNITED STATES
Summary of Principal and Interest Portions
Summary Of Principal And Interest Portions Table [Text Block]
Tabular disclosure of the principal and interest portions of a finance lease.
Entity Shell Company
Entity Shell Company
Derivatives, Policy [Policy Text Block]
Freestanding Financial Instruments and Derivatives
Former Stockholders and Optionholders [Member]
Former stockholders and optionholders.
Former Stockholders and Optionholders
Leasehold Improvements Landlord Allowance
The monetary allowance granted by the landlord to a tenant to entice tenant to move into landlords building which will enable the tenant to prepare the leased premises for tenants occupancy.
Leasehold improvements landlord allowance
Stock-based compensation expense
Share-Based Payment Arrangement, Expense
Fair Value of Financial Instruments
Fair Value of Financial Instruments, Policy [Policy Text Block]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities
Accrued expenses and other
Equity securities
Equity securities included in marketable securities
Equity securities, Amortized Cost
Equity securities, Fair Value
The year in which net operating loss carryforwards begin to expire.
Net Operating Loss Carryforwards Expiration Starting Year
Net operating loss carryforwards expiration starting year
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value, Recurring and Nonrecurring [Table]
Area Of Facility Being Built
The area of a facility being built for future lease, in square feet.
Manufacturing facility, number of square feet
Loss Contingencies [Line Items]
Security Exchange Name
Security Exchange Name
Class Of Stock [Line Items]
Class of Stock [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Long-term equipment financing liability
Finance Lease, Liability, Noncurrent
Lease Costs Included In Measurement Of Lease Liabilities [Table Text Block]
Tabular disclosure of the lease costs included in the measurement of lease liabilities.
Summary of Lease Costs Included in Measurement of Lease Liabilities
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Net cash provided by (used in) operating activities
Net Cash Provided by (Used in) Operating Activities
Proceeds From Finance Lease
Amount of cash inflow from draw down on funds for a finance lease.
Proceeds from equipment financings
Unrecognized compensation cost, cost to recognize over a weighted-average period
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Net operating loss carryforwards not subject to expiration
Operating Loss Carryforward Not Subject To Expiration
Amount of operating loss carryforward that is not subject to expiration.
Expected Term (years)
Measurement Input, Expected Term [Member]
Operating lease costs
Operating Lease, Cost
Interest and Other Income (Expense)
Interest and Other Income (Expense), Net
Interest And Other Income Expense [Member]
Interest and other income (expense).
Business combination transaction price allocated.
Business Combination Transaction Price Allocated [Abstract]
Transaction price allocated
Tax credits expiration starting year
Tax Credits Expiration Starting Year
The year in which specified tax credits begin to expire.
Number of shares issued to satisfy success payment obligation.
Issuance of common stock for success payment liability, Shares
Issuance of common stock for success payment liability, Shares
Issuance of common stock for success payment liability, Shares
Summary of Future Minimum Lease Payments of Operating Leases
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Sublease Area Of Rented Space
The amount of space to be subleased, in square feet.
Sublease area of rented space
Principles of Consolidation
Consolidation, Policy [Policy Text Block]
2024
Finance Lease, Liability, to be Paid, Year Two
Potential Consideration
Potential total consideration
Potential aggregate consideration that may be received as part of a collaboration agreement.
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles
Intangible assets
Summary of Option Activity Under Equity Award Plans
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Recently adopted accounting pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Common stock, shares outstanding
Common Stock, Shares, Outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Business Acquisition [Line Items]
Underwriters Option
Over-Allotment Option [Member]
Research and development tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent
Level 2
Fair Value, Inputs, Level 2 [Member]
Debt Securities, Available-for-sale, Total
Marketable securities
Available-for-sale, Fair Value
Research Plan
Research Plan [Member]
Research plan.
Investing activities
Net Cash Provided by (Used in) Investing Activities [Abstract]
Commitments and contingencies (See Note 7, Leases, Note 10, License agreements and Note 11, Collaboration and license agreements)
Commitments and Contingencies
Income Tax Authority, Name [Domain]
Milestone payment shares issued
Common stock, shares issued
Common Stock, Shares, Issued
Common Stock, Shares, Issued, Total
Obligation to Issue Common Stock Value
The value of stock the Company is obligated to issue to the Collaborator if the Company elects to extend the collaboration.
Obligation to issue common stock value
Collaboration Arrangement Initial Term
Collaboration arrangement initial term.
Collaboration arrangement, initial term
U.S. Treasury Securities
US Treasury Securities [Member]
Measurement Input Probability Of Achievement [Member]
Measurement Input Probability Of Achievement [Member]
Probability of Achievement
Minimum
Minimum
Minimum [Member]
Common stock, shares description
Share-Based Compensation Arrangement by Share-Based Payment Award, Description
Revenue Remaining for Each Performance Obligation
Revenue remaining for each performance obligations
The amount of revenue allocated to each performance obligation.
Income Tax Authority, Name [Axis]
License Agreements
License Agreement Disclosure [Text Block]
The entire disclosure for licensing arrangements with third parties, which includes, but is not limited to, success payments and milestone payments.
Merger Agreement
Merger Agreement [Member]
Merger agreement.
Guide Merger Agreement
Interest and other income (expense), net
Interest And Other Income Expense Net
Amount of interest income and income (expense) related to nonoperating activities classified as other.
Leases and Rent Expense
Lessee, Leases [Policy Text Block]
Exercisable as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
2017 Plan
Two Thousand Seventeen Stock Option And Grant Plan [Member]
Two thousand seventeen stock option and grant plan.
Operating Lease Rent Payments Begin Month And Year
The month and year in which the rent payments will begin under an operating lease.
Rent payments beginning month and year
Accounting Standards Update [Axis]
Accrual liability
Accrued Liabilities, Current
Accrued Liabilities, Current, Total
Stockholders' Equity Attributable to Parent [Abstract]
Stockholders' equity:
State income taxes, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Counterparty Name [Axis]
Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Canceled
Award Type
Award Type [Axis]
Other
Other Noncash Income (Expense)
Other Noncash Income (Expense), Total
Subsequent Event
Subsequent Event [Member]
Business Combination, Consideration Transferred
Total transaction price
Related Party Transaction
Related Party Transaction [Domain]
Total deferred tax assets
Deferred Tax Assets, Gross
Loss Contingencies [Table]
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Aggregate intrinsic value of stock options exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Collaboration agreement term of contract.
Collaboration Agreement Term of Contract
Collaboration agreement term of contract
Dividend received
Investment Income, Dividend
Research and development
Research and Development Expense, Total
Research and development expense
Undiscounted lease payments
Lessee, Operating Lease, Liability, to be Paid
Financing obligations, leased back equipment term of contract
Lessee, Finance Lease, Term of Contract
Collaboration License Agreement Fair Value of Shares Received
Collaboration license agreement fair value of shares received
The fair value of shares received as part of a collaboration and license agreement.
Laboratory Space
Laboratory Space [Member]
Laboratory space.
Operating lease term
Lessee, Operating Lease, Term of Contract
Equity Securities, FV-NI, Cost
Equity securities, Fair Value
Equity securities, Amortized Cost
Change in operating lease right-of-use assets
Increase Decrease In Operating Lease Right Of Use Asset
Increase (decrease) in operating lease right of use asset.
Finance Lease Liability Payments [Table]
Finance Lease Liability Payments [Table]
Finance lease liability payments.
Entity Central Index Key
Entity Central Index Key
Increase in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Verve
Verve [Member]
Verve.
Business Combination, Contingent Consideration, Liability, Noncurrent
Contingent consideration liabilities
Claims outstanding
Guarantor Obligations, Current Carrying Value
Numerator:
Net Income (Loss) Attributable to Parent [Abstract]
Accounting Policies [Abstract]
Accrued expenses and other liabilities
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Fair Value of Common Stock
Measurement Input Fair Value Of Common Stock [Member]
Measurement input fair value of common stock.
Investments, Debt and Equity Securities [Abstract]
Litigation Case [Axis]
Laboratory Equipment and Office Furniture
Laboratory Equipment And Office Furniture [Member]
Laboratory equipment and office furniture.
Debt Securities, Available-for-Sale [Line Items]
Less accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
ASU 2022-03
Accounting Standards Update 2022-03 [Member]
Accounting standards update 2022-03.
Schedule Of Property Plant And Equipment [Table]
Property, Plant and Equipment [Table]
Number of Shares Purchased Under Equity Method
Number of shares purchased under equity method.
Number of shares purchased under equity method
Broad Institute.
Broad Institute [Member]
Broad Institute
Measurement Frequency
Measurement Frequency [Axis]
Number of shares available for future issuance
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Stock Option and Grant Plan
Share-Based Payment Arrangement [Text Block]
Redeemable Convertible Preferred Stock
Redeemable Convertible Preferred Stock [Member]
Collaboration agreement performance obligation revenue period for recognition
Collaboration Agreement Performance Obligation Revenue Period For Recognition
The period over which revenue is expected to be recognized as part of a collaboration agreement.
General and administrative
General and Administrative Expense
General and Administrative Expense, Total
Measurement Input Type
Measurement Input Type [Domain]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Schedule of Equity Method Investments [Table]
Outstanding as of December 31, 2022
Outstanding as of December 31, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted-average exercise price
Business Combination, Contingent Consideration Arrangements, Description
Milestone payment method, description
Paydown of principal
Finance Lease, Principal Payments
Repayment of equipment financings
Success payments liability
Success Payment Liability
The amount of liability incurred for success payments.
Research and Development Expense
Research and Development
Research and Development Expense [Member]
Issuance of common stock related to license agreement
Issuance Of Common Stock Value Related To License Agreement
Value of stock issued during the period related to a license agreement.
Forecast [Member]
Forecast
Total
Lease, Cost
Operating lease liabilities arising from obtaining right-of-use assets
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Operating lease liabilities arising from obtaining ROU assets
Employer matching contribution to 401(k) Plan as a percentage of employee's eligible earnings
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Accumulated Deficit
Retained Earnings [Member]
Security Deposit
Lessee, operating lease, security deposit
Collaborative Arrangement, Rights and Obligations
Collaborative arrangement rights and obligations, description
Loss from equity method investment
Loss from equity method investment
Income (Loss) from Equity Method Investments
Assigned to Pfizer.
Assigned to Pfizer [Member]
Assigned to Pfizer
Jeffries LLC Sales Agreement And Amended Sales Agreement [Member]
Jeffries LLC Sales Agreement and Amended Sales Agreement.
Jeffries LLC Sales Agreement and Amended Sales Agreement
Money Market Funds
Money Market Funds [Member]
Measurement Input Type
Measurement Input Type [Axis]
Total
Effective Income Tax Rate Reconciliation, Percent
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Assembled Workforce [Member]
Assembled Workforce.
Assembled Workforce
Business Combination, Consideration Transferred, Equity Interests Issued and Issuable
Fair value of equity instruments issued
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Total property and equipment
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Operating Lease Term And Discount Rate [Table Text Block]
Tabular disclosure of the lease term and discount rate for an operating lease.
Summary of Lease Term and Discount Rate
Commission rate
Commission Rate
The commission rate the Company agreed to pay for all shares sold under a Sales Agreement, as a percentage of gross sales proceeds.
Additional paid-in capital
Additional Paid in Capital
Additional Paid in Capital, Total
Additional Paid in Capital, Beginning Balance
Additional Paid in Capital, Ending Balance
Entity Interactive Data Current
Entity Interactive Data Current
Tax credits
Tax Credit Carryforward, Amount
Entity Public Float
Entity Public Float
Scientific Consulting and Other Expenses
Scientific Consulting And Other Expenses [Member]
Scientific consulting and other expenses.
Per Program
Per Program [Member]
Per program.
Related Party Transactions
Related Party Transactions Disclosure [Text Block]
Technology and product contingent consideration liabilities
Business combination liability for milestones at fair value
Business Combination Consideration Transferred Technology And Product Contingent Consideration Liabilities
Amount of contingent consideration liability for technology and product milestones incurred by the acquirer.
Supplemental disclosure of non-cash investing and financing activities:
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Effective Income Tax Rate Reconciliation In Process Research And Development Acquisition
IPR&D Guide Acquisition
Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to acquisition related in process research and development expenses.
Editas License Agreement
Editas License Agreement [Member]
Editas License Agreement.
Related Party Transactions [Abstract]
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
2019 Plan
Two Thousand Nineteen Equity Incentive Plan [Member]
Two thousand nineteen equity incentive plan.
Prime Agreement [Member]
Prime Agreement
Leasehold Improvements
Leasehold Improvements [Member]
Preferred stock outstanding
Redeemable convertible preferred stock, Beginning Balance, Shares
Redeemable convertible preferred stock, Ending Balance, Shares
Temporary Equity, Shares Outstanding
Gross proceeds from sale of common stock
Proceeds from public offering, net of underwriting discount
Proceeds from Issuance Initial Public Offering
Local Phone Number
Local Phone Number
Federal statutory rate
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Employees, Officers, Founders and Consultants
Employees Officers Founders And Consultants [Member]
Employees, officers, founders and consultants.
Share Based Compensation Arrangement By Share Based Payment Award Payroll Deduction Yearly Limit Amount
The maximum annual amount of funds that employees can contribute through payroll deductions to purchase shares as part of share based compensation plan.
Maximum amount allowed to purchase common stock using payroll deduction
Total
Accrued expenses and other current liabilities
Accrued Expenses And Other Current Liabilities
Amount of expenses incurred but not yet paid nor invoiced, and liabilities classified as other, payable within one year or the normal operating cycle, if longer.
Summary of Computation of Basic and Diluted Net Loss per Share Attributable to Common Stockholders
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Research and Development Expense Offset Amount
Research and development expense offset amount.
Research and development expense offset amount
Schedule of Change in Fair Value of Success Payment Liability
Schedule Of Change In Fair Value Of Success Payment Liability Table [Text Block]
Tabular disclosure of the change in fair value of the success payment liability arising from a licensing agreement.
Vesting period
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Option Rights Aggregate Potential Additional Consideration
Option rights aggregate potential additional consideration
The aggregate amount of potential fee for additional option rights.
October 2020 Public Offering
October Two Thousand Twenty Public Offering [Member]
October 2020 Public offering.
Collaboration arrangement extension term description
Collaboration Arrangement Extension Term Description
The description of the extension term of a collaboration arrangement.
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Basis of Presentation
Basis of Accounting, Policy [Policy Text Block]
Lease Contractual Term
Lease Contractual Term [Axis]
Exercisable as of December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Lessee, Operating Lease, Description
Lessee operating lease, description
Proceeds from issuance of Series B Preferred Stock, net
Proceeds from Issuance of Preferred Stock and Preference Stock
IPO
IPO [Member]
Equity Securities, FV-NI, Unrealized Gain (Loss), Total
Equity Securities, FV-NI, Unrealized Gain (Loss)
Unrealized gains on investment
Operating lease, existence of option to extend
Lessee, Operating Lease, Existence of Option to Extend [true false]
Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Accretion of redeemable convertible preferred stock to redemption value, including dividends on preferred stock
Accretion of redeemable convertible preferred stock to redemption value, including dividends on preferred stock
Temporary Equity, Accretion to Redemption Value, Adjustment
2019 Employee Stock Purchase Plan
Two Thousand Nineteen Employee Stock Purchase Plan Member
Two thousand nineteen employee stock purchase plan.
Other liabilities
Other Liabilities, Noncurrent
Other Liabilities, Noncurrent, Total
Schedule of Calculation of Estimated Fair Value of Success Payment Liabilities
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]
Schedule of change in Fair Value of Liabilities based on Level 3 inputs
Reverse stock split ratio
Stockholders' Equity Note, Stock Split, Conversion Ratio
Reverse stock split ratio
Income Statement Location
Income Statement Location [Domain]
The amount of success payment due as part of a license agreement.
Success Payment Amount Due
Success payment amount due
Nature Of Business And Basis Of Presentation [Line Items]
Nature Of Business And Basis Of Presentation [Line Items]
Nature of the business and basis of presentation.
Property, Plant and Equipment [Abstract]
Summary Of Other Income (Expense) Incurred Due To Changes In Fair Value Of Corporate Equity Securities Held
Debt Securities, Trading, and Equity Securities, FV-NI [Table Text Block]
Unvested as of December 31, 2022
Unvested as of December 31, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Beginning Balance, Shares
Ending Balance, Shares
Shares, Outstanding
Transaction costs
Business Acquisition Cost Of Acquired Entity Transaction Cost
Amount of transactions costs incurred by the acquirer.
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Contingent Consideration by Type [Axis]
Outstanding as of December 31, 2022
Outstanding as of December 31, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Document Fiscal Year Focus
Document Fiscal Year Focus
Change in operating lease liability
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Increase (decrease) in operating lease liabilities.
Noncash or Part Noncash Acquisition, Value of Liabilities Assumed, Total
Noncash or Part Noncash Acquisition, Value of Liabilities Assumed
Contingent consideration liabilities assumed in asset acquisition
Monthly Service Fee
Monthly Service Fee [Member]
Monthly service fee.
Schedule of Business Acquisitions, by Acquisition [Table Text Block]
Summary of Transaction Price Determined and Allocated
2024
Lessee, Operating Lease, Liability, to be Paid, Year Two
Collaboration Agreement Aggregate Transaction Price
The aggregate transaction price of a collaboration agreement.
Collaboration agreement aggregate transaction price
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per common share attributable to common stockholders, basic
Available For Sale Debt Securities and Equity Securities FV-Ni Current
Marketable securities
Amount of investment in debt and equity securities measured at fair value, classified as available-for-sale.
Weighted average exercise price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Employee Benefits
Compensation and Employee Benefit Plans [Text Block]
Assets
Assets [Abstract]
Revenue, remaining for each performance obligation, expected timing of satisfaction, period.
Revenue, Remaining For Each Performance Obligation, Expected Timing of Satisfaction, Period
Revenue remaining performance obligation, expected timing of satisfaction, period
Deferred tax assets, net
Deferred Tax Assets, Net
Expected volatility
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum
Prepaid expenses and other current assets
Prepaid Expense and Other Assets, Current
Price per share of stock sold
Shares Issued, Price Per Share
Public offering price per share
Rental Payment Over Term of Sublease
The amount of rental payments the Company is expected to receive over the term of a sublease.
Rental payment over term of sublease
Stock Issuance Program Authorized Amount
Amount of shares authorized to be issued under a stock issuance program.
Aggregate gross proceeds of shares authorized under ATM sales agreement
Series A Preferred Stock Shares
Series A Preferred Stock
Series A Preferred Stock [Member]
Financial Instrument
Financial Instrument [Axis]
Asset Acquisitions [Policy Text Block]
Disclosure of accounting policy for asset acquisitions, both as part of a business combination and not as part of a business combination.
Asset Acquisitions
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Axis]
Deferred revenue
Deferred Tax Assets, Deferred Income
Collaboration agreement transaction price for each performance obligations.
Collaboration Agreement Transaction Price for Each Performance Obligations
Collaboration agreement transaction price to each of six performance obligations
The term over which capitalized research and development costs will be amortized for tax purposes.
Amortized R&D tax purpose year
Amortization of R&D Tax Term
Number of options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward]
Liabilities, redeemable convertible preferred stock, and stockholders’ equity (deficit)
Liabilities and Equity [Abstract]
Liabilities and stockholders' equity
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Income Tax Authority
Income Tax Authority [Axis]
Valuation Approach and Technique [Axis]
Summary of Restricted Stock Activity
Nonvested Restricted Stock Shares Activity [Table Text Block]
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Available For Sale Debt Securities and Equity Securities FV-Ni Amortized Cost Basis
Marketable securities held, Amortized Cost
Amortized cost of investment in debt and equity securities measured at fair value (available-for-sale).
Current assets:
Assets, Current [Abstract]
Massachusetts
MASSACHUSETTS
Tabular disclosure of the estimated useful lives of property, plant and equipment.
Estimated Useful Life of Property and Equipment
Schedule Of Property And Equipment Estimated Useful Life Table [Text Block]
Bio Palette License Agreement
Bio Palette License Agreement [Member]
Bio Palette License Agreement.
Schedule of Components of Deferred Taxes
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Other
Deferred Tax Liabilities, Other
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Employer matching contribution to 401(k)
Defined Contribution Plan, Employer Discretionary Contribution Amount
Payables and Accruals [Abstract]
Other Payments.
Other Payments [Member]
Other Payments
Measurement Frequency
Measurement Frequency [Domain]
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Increase Decrease in Collaboration Receivable
The increase (decrease) during the reporting period in amount due within one year (or one business cycle) as part of a collaboration agreement.
Collaboration receivable
Collaboration receivable
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Entity
Entity [Domain]
The aggregate amount the Company is obligated to pay upon achievement of specified milestones.
Aggregate Milestone Amount
Aggregate milestone amount
Cover [Abstract]
Interest or penalties for unrecognized tax benefits since inception
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
Product and Service
Product and Service [Domain]
Measurement Basis
Measurement Basis [Axis]
2027
Lessee, Operating Lease, Liability, to be Paid, Year Five
Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Product Development and Regulatory Approval.
Product Development and Regulatory Approval [Member]
Product Development and Regulatory Approval
Nonrefundable upfront payment receivable deferred revenue liability
Nonrefundable Upfront Payment Receivable Deferred Revenue Liability
Nonrefundable upfront payment receivable deferred revenue liability.
Current liabilities:
Liabilities, Current [Abstract]
Maximum
Maximum [Member]
Dispute with Research Institution
Dispute With Research Institution [Member]
Dispute with Research Institution.
Employer matching contribution to 401(k) Plan as a percentage of employee's contribution
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
Summary of Stock-based Compensation Expense
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Net Cash Provided by (Used in) Investing Activities
Net cash used in investing activities
Furniture and Fixtures
Furniture and Fixtures [Member]
Other income (expense)
Other income (expense)
Equity securities recognition amount
Change in fair value of non-controlling equity investments
Change in fair value of non-controlling equity investments
Change in fair value of equity investments
Computer Equipment and Software
Computer Equipment And Software [Member]
Computer equipment and software.
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Exercised
Exercise of common stock options, Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Level 3
Fair Value, Inputs, Level 3 [Member]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Vesting of restricted common stock, Shares
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Success payment liability
Derivative Liability, Subject to Master Netting Arrangement, before Offset
Derivative Liability, Fair Value, Gross Liability, Total
Finance Lease Liability Payments [Line Items]
Finance Lease Liability Payments [Line Items]
Finance lease liability payments.
Exercise of common stock options
Stock Issued During Period, Value, Stock Options Exercised
Segment and Geographic Information
Segment Reporting, Policy [Policy Text Block]
Property and equipment, estimated useful life
Property, Plant and Equipment, Useful Life
Contingent consideration of technology liabilities.
Contingent Consideration Of Technology Liabilities [Member]
Technology Milestones
Consideration of Technology Liabilities
The amount of upfront payment received under the terms of an agreement.
Upfront Payment Received Under Term of Agreement
Upfront payment received under term of agreement
Alternate investment, measurement input
Alternative Investment, Measurement Input
Common stock, shares authorized
Common Stock, Shares Authorized
Harvard
Harvard License Agreement [Member]
Harvard license agreement.
Harvard
Accrued Sub License Fees Current
Accrued sub-license fees
Amount of expenses incurred but not yet paid for sub-license fees, payable within one year or the normal operating cycle, if longer.
Trading Symbol
Trading Symbol
First Phase of Lease in October 2020
Commencement Of First Phase Of Lease In October Twenty Twenty [Member]
Commencement of first phase of lease in October 2020.
The amount of upfront fee receivable upon signing of a collaboration agreement.
Upfront fee receivable upon signing contract
Title of Individual
Title of Individual [Domain]
Subsequent Event Type
Subsequent Event Type [Axis]
Balance Sheet Location
Balance Sheet Location [Axis]
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Weighted-average risk-free interest rate
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Accounts payable
Accounts Payable, Current
Accounts Payable, Current, Total
Collaboration License Agreement Shares Received
The number of shares of stock received as part of a collaboration and license agreement.
Number of common stock received
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Available-for-sale, Gross Unrealized Losses
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements
Payments
Plan Name
Plan Name [Axis]
Schedule Of Related Party Transactions By Related Party [Table]
Schedule of Related Party Transactions, by Related Party [Table]
Title of Individual
Title of Individual [Axis]
Internal Revenue Service (IRS) [Member]
IRS
Long-Lived Tangible Asset
Long-Lived Tangible Asset [Domain]
Common stock, par or stated value per share
Common Stock, Par or Stated Value Per Share
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Stock Issued During Period, Shares, Acquisitions
Issuance of common stock to acquire Guide, Shares
Variable lease costs
Variable Lease, Cost
Amortization
Deferred Tax Assets Amortization
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from amortization.
Corporate Equity Securities [Member]
Corporate equity securities.
Corporate Equity Securities
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering
Stock Issued During Period, Value, Conversion of Convertible Securities
Regulatory
Regulatory [Member]
Regulatory
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
Issuance of restricted common stock
Issued
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Stock Issued During Period, Value, Acquisitions
Value of shares issued for upfront payment of acquisition
Issuance of common stock to acquire Guide
License and collaboration agreement outstanding common stock held percentage
License and Collaboration Agreement Outstanding Common Stock Held Percentage
The amount of outstanding common stock held by the Company as part of a license and collaboration agreement, as a percentage.
Property and Equipment, Net
Property, Plant and Equipment Disclosure [Text Block]
Property and equipment, estimated useful life
Property, Plant and Equipment, Estimated Useful Lives
Granted
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Fair Value
Estimate of Fair Value Measurement [Member]
Shares issued and sold
Stock Sold During Period Shares, New Issues
Number of new shares sold, but not necessarily issued, during the period.
Stock sold during period shares, new issues
Antidilutive shares excluded from computation of diluted net loss per share
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Other income (expense):
Other Operating Income Expense [Abstract]
Other Operating Income Expense.
Cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Summary of Future Minimum Payments Related to Equipment Financing Obligations
Finance Lease, Liability, Fiscal Year Maturity [Table Text Block]
Success payment liabilities.
Success Payment Liabilities [Member]
Success Payment Liabilities
Other long-term assets
Increase (Decrease) in Other Noncurrent Assets