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Collaboration Arrangement Extension Term Sublease income Sublease Income Sublease income Operating Loss Carryforwards, Total Operating Loss Carryforwards Net operating loss carryforwards Lessee, Operating Lease, Renewal Term Operating lease, option to extend term Settlement Agreement Settlement Agreement [Member] Settlement Agreement. Proceeds from Stock Plans Proceeds from issuances of stock under ESPP Commitments and Contingencies Commitments and contingencies (See Note 9, License and other agreements and Note 10, Collaboration and license agreements) Commitments and contingencies (See Note 9, License and other agreements and Note 10, Collaboration and license agreements) Lessee, Leases [Policy Text Block] Leases and Rent Expense Apellis Pharmaceuticals, Inc Apellis Pharmaceuticals, Inc. Apellis Pharmaceuticals Inc [Member] Apellis Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Unvested as of December 31, 2025 Unvested as of December 31, 2024 General and Administrative Expense [Member] General and Administrative General And Administrative Expenses [Member] Total operating lease liabilities Lease liability Operating Lease, Liability, Total Operating Lease, Liability Auditor Firm ID Sravan K Emany Sravan K Emany [Member] Sravan K Emany. Debt Instrument, Basis Spread on Variable Rate Inerest rate Number of founder shareholders. Number Of Founder Shareholders Number of founder shareholders Reverse stock split Stockholders' Equity, Reverse Stock Split Reverse stock split Jeffries LLC Amended Sales Agreement Jeffries LLC amended sales agreement. 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Entity File Number Entity File Number Cover Cover [Abstract] Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum Expected volatility Measurement Input Type [Axis] Measurement Input Type Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from lease liabilities. Deferred Tax Assets Leasing Arrangements Lease liability Cumulative Effect, Period of Adoption [Axis] Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Forfeited Forfeited Amount, before tax, of unrealized gain on investment in debt and equity securities measured at fair value (available-for-sale). 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Conversion of shares into cash Conversion of shares into cash Derivative, Term of Contract Success payment liability, term Property, Plant and Equipment, Useful Life Property and equipment, estimated useful life New Accounting Pronouncements, Policy [Policy Text Block] Recently Adopted Accounting Pronouncements Summary of Future Maturity of Operating Leases Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] Current portion of deferred revenue Contract with Customer, Liability, Current Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent Other Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period Vesting period Manufacturing facility, number of square feet The area of a facility being built for future lease, in square feet. 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Contingent obligations and non-royalty sublicense fees Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense Interest or penalties for unrecognized tax benefits since inception Lessee, Operating Lease, Term of Contract Operating lease term Summary of Lease Costs Included in Measurement of Lease Liabilities Tabular disclosure of the lease costs included in the measurement of lease liabilities. Lease Costs Included In Measurement Of Lease Liabilities [Table Text Block] Common Stock, Shares, Outstanding, Ending Balance Common Stock, Shares, Outstanding, Beginning Balance Common Stock, Shares, Outstanding Common stock, shares outstanding Operating Lease, Liability, Current Current portion of lease liability Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] Depreciation and amortization Depreciation, Depletion and Amortization Depreciation, Depletion and Amortization, Total Accounting Standards Update 2025 07 [Member] Accounting standards update 2025 07. ASU 2025-07 Cybersecurity Risk Management Processes Integrated [Flag] Document Transition Report Document Transition Report Unamortized Domestic Research and Experimental Expenditures Unamortized domestic research and experimental expenditures. Unamortized domestic research and experimental expenditures Deferred Tax Assets, Net Total Operating Expenses Total operating expenses Research and development expense Research and Development Expense, Total Research and development Research and development expenses Leases Lessee, Operating Leases [Text Block] Accrued Contingent Obligation License Agreement Current Amount of liability recognized arising from contingent consideration in a licensing agreement, expected to be settled within one year or the normal operating cycle, if longer. Accrued contingent obligation Interest and other income (expense). Interest And Other Income Expense [Member] Interest and Other Income (Expense), Net Interest and Other Income (Expense) Direct Financing Lease, Residual Value of Leased Asset Plus: residual values Statement of Cash Flows [Abstract] Transaction price allocated Business Combination Transaction Price Allocated [Abstract] Business combination transaction price allocated. The year in which specified tax credits begin to expire. Tax Credits Expiration Starting Year Tax credits expiration starting year Issuance of common stock for success payment liability, Shares Issuance of common stock for success payment liability, Shares Issuance of common stock for success payment liability, Shares Number of shares issued to satisfy success payment obligation. Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Weighted-average grant date fair value Sublease area of rented space The amount of space to be subleased, in square feet. Sublease Area Of Rented Space Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs Value of common stock shares issued Stock Issued During Period, Value, New Issues Share-Based Payment Arrangement, Option, Activity [Table Text Block] Summary of Option Activity Under Equity Award Plans Assets, Fair Value Disclosure [Abstract] Assets Potential total consideration Potential Consideration Potential aggregate consideration that may be received as part of a collaboration agreement. Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent Stock-based compensation expense Stock-based compensation Payments to Acquire Businesses, Net of Cash Acquired Payments to Acquire Businesses, Net of Cash Acquired, Total Cash paid for acquisition, net Common Stock Equity [Text Block] Earnings Per Share [Text Block] Net Loss per Share Attributable to Common Stockholders Deferred Tax Liabilities, Other Other Development, Clinical and Commerical Milestones [Member] Development, clinical and commerical milestones. Development, Clinical and Commerical Milestones Computer Equipment [Member] Computer Equipment Cybersecurity Risk Management Processes Integrated [Text Block] Fair value of common stock sold Sale of Stock, Consideration Received Per Transaction Net loss Net loss Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value Outstanding Research plan. Research Plan [Member] Research Plan Operating Lease, Cost Operating lease costs Obligation to issue common stock value The value of stock the Company is obligated to issue to the Collaborator if the Company elects to extend the collaboration. Obligation to Issue Common Stock Value Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate Expected dividend yield Liability Recognized On Contingent Payments Liability recognized on contingent payments. Liability recognized on contingent payments Collaboration arrangement, initial term Collaboration arrangement initial term. Collaboration Arrangement Initial Term Liability for Uncertainty in Income Taxes, Current Uncertain tax positions Probability of Achievement Measurement Input Probability Of Achievement [Member] Measurement Input Probability Of Achievement [Member] Operating Lease, Payments Operating cash flows used for operating leases Assets [Abstract] Assets Development and Regulatory Milestones [Member] Development and regulatory milestones. Development and Regulatory Milestones Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Weighted-average risk-free interest rate Construction in Progress [Member] Construction in Process Increase (Decrease) in Prepaid Expense and Other Assets, Total Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets Restructuring and Related Activities [Abstract] Document Fiscal Year Focus Document Fiscal Year Focus The entire disclosure for licensing arrangements with third parties, which includes, but is not limited to, success payments and milestone payments. License Agreement Disclosure [Text Block] License Agreements Guide Merger Agreement Merger agreement. Merger Agreement [Member] Merger Agreement Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract] Investing activities Retirement Benefits [Abstract] Amount of interest income and income (expense) related to nonoperating activities classified as other. Interest And Other Income Expense Net Interest and other income (expense), net Accounts Payable, Current, Total Accounts Payable, Current Accounts payable Research and Development Expense [Member] Research and Development Research and Development Expense Two thousand seventeen stock option and grant plan. Two Thousand Seventeen Stock Option And Grant Plan [Member] 2017 Plan Rent payments beginning month and year The month and year in which the rent payments will begin under an operating lease. Operating Lease Rent Payments Begin Month And Year Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Marketable Securities Proceeds from potential future development-stage upfront payments Proceeds From Transfer Agreement The amount of proceeds the Company received as part of a transfer agreement. Defined Contribution Plan, Employer Matching Contribution, Percent of Match Employer matching contribution to 401(k) Plan as a percentage of employee's contribution Increase (Decrease) in Other Noncurrent Assets Other long-term assets Summary of Changes in Total Deferred Revenue Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block] Change in fair value of equity investments Change in fair value of non-controlling equity investments Change in fair value of non-controlling equity investments Equity securities recognition amount Other income (expense) Other income (expense) Restructuring Cost and Reserve [Line Items] Components of Deferred Tax Assets [Abstract] Deferred tax assets: Proceeds from Stock Options Exercised Proceeds from exercise of stock options Fair Value Disclosures [Abstract] Issuance of common stock to acquire Guide Value of shares issued for upfront payment of acquisition Stock Issued During Period, Value, Acquisitions Tax Credits Effective Income Tax Rate Reconciliation, Tax Credit, Amount Effective Income Tax Rate Reconciliation, Tax Credit, Amount, Total Lessee, Operating Lease, Liability, to be Paid, Year One 2026 Shares issued and sold Sale of Stock, Consideration Received on Transaction Net proceeds from sale of common stock Net loss Net Income (Loss) Available to Common Stockholders, Basic Net loss attributable to common stockholders Collaboration agreement term of contract Collaboration Agreement Term of Contract Collaboration agreement term of contract. Long-Term Line of Credit Long-Term Line of Credit, Total outstanding amount Debt Instrument [Axis] Thereafter Lessee, Operating Lease, Liability, to be Paid, after Year Five The fair value of shares received as part of a collaboration and license agreement. Collaboration license agreement fair value of shares received Collaboration License Agreement Fair Value of Shares Received Share-Based Payment Arrangement [Abstract] Laboratory space. Laboratory Space [Member] Laboratory Space Total assets Assets, Fair Value Disclosure Total Assets Sale of Stock [Axis] Sale of Stock Freestanding Financial Instruments and Derivatives Derivatives, Policy [Policy Text Block] Increase (decrease) in operating lease right of use asset. Increase Decrease In Operating Lease Right Of Use Asset Change in operating lease right-of-use assets Finance lease liability payments. Finance Lease Liability Payments [Table] Finance Lease Liability Payments [Table] Workforce Reduction Workforce Reduction [Member] Workforce Reduction [Member] Net cash provided by (used in) investing activities Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Verve. Verve [Member] Verve Private Placement [Member] Private Placement Title of 12(b) Security Title of 12(b) Security Schedule of Segment Reporting Information, by Segment [Table] Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Amount Stock-based compensation Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Forfeited Canceled Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Forfeited Money Market Funds [Member] Money Market Funds Related and Nonrelated Parties [Domain] Related Party Income Tax Disclosure [Text Block] Income Taxes Measurement input fair value of common stock. Measurement Input Fair Value Of Common Stock [Member] Fair Value of Common Stock Collaborative Arrangement and Arrangement Other than Collaborative [Table] Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table] Laboratory equipment and office furniture. Laboratory Equipment And Office Furniture [Member] Laboratory Equipment and Office Furniture Employee Related Expenses [Member] Employee Related Expenses [Member] Employee related expenses. Number of shares purchased under equity method Number of shares purchased under equity method. Number of Shares Purchased Under Equity Method Broad Institute Broad Institute [Member] Broad Institute. Other Liabilities, Noncurrent, Total Other Liabilities, Noncurrent Other liabilities Restructuring Plan [Domain] Legal Entity [Axis] Legal Entity Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: The amount of purchased research and development assets that are acquired in a business combination have no alternative future use and are therefore written off in the period of acquisition. 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The period over which revenue is expected to be recognized as part of a collaboration agreement. Collaboration Agreement Performance Obligation Revenue Period For Recognition Collaboration agreement performance obligation revenue period for recognition Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Accrued expenses and other liabilities Measurement Frequency [Domain] Measurement Frequency Statement of Income Location, Balance [Axis] Income Statement Location The amount of liability incurred for success payments. Success Payment Liability Success payments liability Change in Accounting Principle, Accounting Standards Update, Adoption Date Change in Accounting Principle, Accounting Standards Update, Adoption Date Trading Symbol Trading Symbol Property, Plant and Equipment Disclosure [Text Block] Property and Equipment, Net Change in fair value Liabilities, Fair Value Adjustment Delayed Draw A [Member] Delayed Draw A. Related Party Transaction [Table] Schedule Of Related Party Transactions By Related Party [Table] Equity securities Equity securities, Fair Value Equity securities, Amortized Cost Equity securities included in marketable securities Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total Nondeductible/ nontaxable permanent items Nondeductible/ nontaxable permanent items Subsequent Event Type [Axis] Subsequent Event Type Employee-related Liabilities, Current, Total Employee-related Liabilities, Current Employee compensation and related benefits Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract] Financing activities Lessee, Finance Lease, Term of Contract Financing obligations, leased back equipment term of contract Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Expected term (in years) Fair Value, Recurring [Member] Recurring Proceeds From Sale Of Common Shares And Pre-funded Warrants, Net Of Issuance Costs The cash inflow from the sale of common stock and pre-funded warrants, net of discounts, commissions and fees. Aggregate net proceeds from offering Proceeds from issuance of common shares and pre-funded warrants, net of issuance costs Schedule of Equity Method Investments [Line Items] Lessee, Operating Lease, Liability, to be Paid Undiscounted lease payments Assigned to Pfizer Assigned to Pfizer [Member] Assigned to Pfizer. Lessee, Operating Lease, Liability, Undiscounted Excess Amount Less: imputed interest Jeffries LLC Sales Agreement and Amended Sales Agreement Jeffries LLC Sales Agreement and Amended Sales Agreement. Jeffries LLC Sales Agreement And Amended Sales Agreement [Member] Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent Research and development tax credits Equity Components [Axis] Equity Components Deferred Tax Assets, Derivative Instruments Derivative liabilities Assembled Workforce Assembled Workforce. Assembled Workforce [Member] Cumulative Effect Of Adoption Of Accounting Standard Update Cumulative effect of adoption of accounting standard update Cumulative effect of adoption of ASU Total other income (expense) Nonoperating Income (Expense) Equity Component [Domain] Equity Component Asset Class [Axis] Asset Class Summary of Lease Term and Discount Rate Tabular disclosure of the lease term and discount rate for an operating lease. Operating Lease Term And Discount Rate [Table Text Block] The commission rate the Company agreed to pay for all shares sold under a Sales Agreement, as a percentage of gross sales proceeds. Commission Rate Commission rate Deferred Tax Assets, Deferred Income Deferred revenue Document Annual Report Document Annual Report Scientific consulting and other expenses. Scientific Consulting And Other Expenses [Member] Scientific Consulting and Other Expenses Business Combination [Axis] Business Acquisition Per program. Per Program [Member] Per Program Amount of contingent consideration liability for technology and product milestones incurred by the acquirer. Business Combination Consideration Transferred Technology And Product Contingent Consideration Liabilities Business combination liability for milestones at fair value Technology and product contingent consideration liabilities IPO [Member] IPO Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to acquisition related in process research and development expenses. IPR&D Guide Acquisition Effective Income Tax Rate Reconciliation In Process Research And Development Acquisition Stock Issued During Period, Shares, Employee Stock Purchase Plans Purchase of common stock under ESPP, Shares Editas License Agreement. Editas License Agreement [Member] Editas License Agreement Potential milestone payments due under settlement agreement Potential Milestone Payments Due Under Settlement Agreement The amount of milestone payments that may become due under a settlement agreement. Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period Expiration period Insider Trading Arr Abstract Insider Trading Arr Abstract Restructuring Charges, Statement of Income or Comprehensive Income [Extensible Enumeration] Depreciation, Depletion and Amortization, Nonproduction Depreciation, Depletion and Amortization, Nonproduction, Total Depreciation and amortization Common Stock, Voting Rights Common stock, voting rights Two thousand nineteen equity incentive plan. Two Thousand Nineteen Equity Incentive Plan [Member] 2019 Plan Maximum Maximum [Member] Maximum [Member] Total liabilities Liabilities, Fair Value Disclosure Total liabilities Statistical Measurement [Axis] Statistical Measurement Weighted-average exercise price of stock options Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Exercised Long-term portion of deferred revenue Contract with Customer, Liability, Noncurrent One-time Termination Benefits One-time Termination Benefits [Member] Opt-in Fee [Member] Opt-in fee . Opt-in Fee Common stock, value Common Stock, Value, Issued, Ending Balance Common Stock, Value, Issued, Beginning Balance Common Stock, Value, Issued, Total Milestone payment value of stock issued Common stock, $0.01 par value; 250,000,000 shares authorized, 101,748,962 and 83,633,069 issued and outstanding at December 31, 2025 and December 31, 2024, respectively Employees, officers, founders and consultants. Employees Officers Founders And Consultants [Member] Employees, Officers, Founders and Consultants Maximum amount allowed to purchase common stock using payroll deduction The maximum annual amount of funds that employees can contribute through payroll deductions to purchase shares as part of share based compensation plan. Share Based Compensation Arrangement By Share Based Payment Award Payroll Deduction Yearly Limit Amount Financing Agreement Financing Agreement [Member] Financing Agreement. Amount of expenses incurred but not yet paid nor invoiced, and liabilities classified as other, payable within one year or the normal operating cycle, if longer. Accrued Expenses And Other Current Liabilities Accrued expenses and other current liabilities Total Research and development expense offset amount Research and development expense offset amount. Research and Development Expense Offset Amount Tabular disclosure of the change in fair value of the success payment liability arising from a licensing agreement. Schedule Of Change In Fair Value Of Success Payment Liability Table [Text Block] Schedule of Change in Fair Value of Success Payment Liability Equipment financings, net Finance Lease, Principal Payments Paydown of principal The aggregate amount of potential fee for additional option rights. Option rights aggregate potential additional consideration Option Rights Aggregate Potential Additional Consideration October 2020 Public offering. October Two Thousand Twenty Public Offering [Member] October 2020 Public Offering The description of the extension term of a collaboration arrangement. Collaboration Arrangement Extension Term Description Collaboration arrangement extension term description Consolidation, Policy [Policy Text Block] Principles of Consolidation Secured Overnight Financing Rate (SOFR) [Member] Equipment [Member] Equipment Payments received from (made to) related parties Related Party Transaction, Amounts of Transaction Outstanding convertible unsecured notes Convertible Notes Payable, Current Deferred Tax Assets, Operating Loss Carryforwards, Total Deferred Tax Assets, Operating Loss Carryforwards Net operating loss carryforwards Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block] Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] Impairment of Long-Lived Assets Accrued liabilities for license fees Accrued Liabilities Accrued Liabilities, Total Two thousand nineteen employee stock purchase plan. Two Thousand Nineteen Employee Stock Purchase Plan Member 2019 Employee Stock Purchase Plan Other Comprehensive Income (Loss), Available-for-Sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent, Total Unrealized gain (loss) on marketable securities Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent State income taxes, net of federal benefit Equity shares value held Equity Shares Value Held The value of shares of equity securities held by the Company. Marketable Securities [Line Items] Success payment amount due Success Payment Amount Due The amount of success payment due as part of a license agreement. Nature of the business and basis of presentation. Nature Of Business And Basis Of Presentation [Line Items] Nature Of Business And Basis Of Presentation [Line Items] Entity Public Float Entity Public Float Percentage of common stock purchase price lower of the fair market value Share-Based Compensation Arrangement by Share-Based Payment Award, Discount from Market Price, Offering Date Common stock offering price discount rate at start of the offering period Preferred Stock, Shares Authorized Preferred stock, shares authorized Proceeds from Collaborators Proceeds from cash consideration Finite-Lived Intangible Assets by Major Class [Axis] Amount of transactions costs incurred by the acquirer. Business Acquisition Cost Of Acquired Entity Transaction Cost Transaction costs Settlement Agreement Upfront Payment The amount of upfront payment the Company has agreed to pay upon signing of a settlement agreement. Settlement agreement upfront payment Manufacturing Facility [Member] Manufacturing Facility Related Party Transaction [Line Items] Related Party Transaction [Line Items] ESPP Employee Stock [Member] Business Combination [Table] Entity Registrant Name Entity Registrant Name Available-for-sale, Gross Unrealized Losses Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Entity Voluntary Filers Entity Voluntary Filers Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table] Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table] Remaining unrecognized revenue recognized Contract with Customer, Liability, Change in Timeframe, Performance Obligation Satisfied, Revenue Recognized Increase (decrease) in operating lease liabilities. Increase Decrease In Operating Lease Liabilities Operating lease liabilities Change in operating lease liability Additional Paid in Capital, Ending Balance Additional Paid in Capital, Beginning Balance Additional Paid in Capital, Total Additional Paid in Capital Additional paid-in capital Equity Securities, FV-NI, Realized Loss Realized loss on sale of marketable securities Subsequent Events [Abstract] Cybersecurity Risk Management Positions or Committees Responsible [Flag] Collaboration agreement aggregate transaction price The aggregate transaction price of a collaboration agreement. Collaboration Agreement Aggregate Transaction Price Effective tax rate Income Tax Expense (Benefit) Income tax expense Provision for income taxes Measurement Frequency [Axis] Measurement Frequency Amount of investment in debt and equity securities measured at fair value, classified as available-for-sale. Marketable securities Available For Sale Debt Securities and Equity Securities FV-Ni Current Upon Achieving Revenue Target from Sales to Certain Date [Member] Upon achieving revenue target from sales to certain date. Stock purchase agreement price Stock Purchase Agreement Amount Received1 Stock Purchase Agreement Amount Received1 Proceeds from issuance of common shares, net of commissions Proceeds from Issuance of Common Stock Business Combination, Contingent Consideration, Type [Axis] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Schedule of Variables Included in Calculation of Estimated Fair Value Fair Value Measurement Inputs and Valuation Techniques [Table Text Block] Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentrations of Credit Risk Increase (Decrease) in Derivative Liabilities Increase (decrease) in long-term portion of derivative liabilities Compensation Related Costs, Policy [Policy Text Block] Stock-Based Compensation Liability Class [Axis] Accumulated Other Comprehensive Income (Loss), Net of Tax, Total Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive (loss) income Payments Payments for Restructuring Payments to Acquire Property, Plant, and Equipment, Total Payments to Acquire Property, Plant, and Equipment Purchases of property and equipment Aggregate gross proceeds of shares authorized under ATM sales agreement Amount of shares authorized to be issued under a stock issuance program. Stock Issuance Program Authorized Amount Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Issued Issuance of restricted common stock Restrictions on Cash and Cash Equivalents [Table Text Block] Reconciliation of Restricted Cash, Cash Equivalents Additional proceeds from potential future development-stage payments Potential Additional Proceeds From Transfer Agreement The amount of additional proceeds the Company may be eligible to receive as part of a transfer agreement. Asset Acquisitions Disclosure of accounting policy for asset acquisitions, both as part of a business combination and not as part of a business combination. Asset Acquisitions [Policy Text Block] Assets Total assets Property, Plant and Equipment [Table] Schedule Of Property Plant And Equipment [Table] Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Exercisable at December 31, 2025 Income Statement [Abstract] Restructuring Cost [Table] Fair Value of Financial Instruments, Policy [Policy Text Block] Fair Value of Financial Instruments Equity Securities, FV-NI, Realized Gain (Loss) Equity Securities, FV-NI, Realized Gain (Loss), Total Realized loss on sale of marketable securities Shares issued and sold Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs, Shares Number of common stock issued Vested Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Consolidation, Variable Interest Entity, Policy [Policy Text Block] Variable Interest Entities Amortized cost of investment in debt and equity securities measured at fair value (available-for-sale). Marketable securities held, Amortized Cost Available For Sale Debt Securities and Equity Securities FV-Ni Amortized Cost Basis Business Combination [Abstract] Net loss per common share, diluted Earnings Per Share, Diluted Earnings Per Share, Diluted, Total Schedule of Reportable Segment Net Revenues and Loss Schedule of Segment Reporting Information, by Segment [Table Text Block] Effective Income Tax Rate Reconciliation, Percent [Abstract] Effective tax rate, Percent Title and Position [Domain] Title of Individual Schedule Of Property And Equipment Estimated Useful Life Table [Text Block] Estimated Useful Life of Property and Equipment Tabular disclosure of the estimated useful lives of property, plant and equipment. Property and equipment, estimated useful life Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration] City Area Code City Area Code Operating Lease Liabilities Increase (Decrease) The increase (decrease) in operating lease liabilities related to right-of-use assets. Operating lease liabilities arising from obtaining right-of-use assets Operating lease liabilities arising from obtaining ROU assets Auditor Name Other Payments Other Payments [Member] Other Payments. Business Combination [Line Items] Collaboration receivable Collaboration receivable The increase (decrease) during the reporting period in amount due within one year (or one business cycle) as part of a collaboration agreement. Increase Decrease in Collaboration Receivable Counterparty Name [Domain] Effective Income Tax Rate Reconciliation, Nondeductible Compensation, Percent Nondeductible compensation Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to limitations on executive compensation. Variable Lease, Cost Variable lease costs Stock Issued During Period, Value, Employee Stock Purchase Plan Purchase of common stock under ESPP Aggregate milestone amount Aggregate Milestone Amount The aggregate amount the Company is obligated to pay upon achievement of specified milestones. Operating Lease, Weighted Average Remaining Lease Term Weighted-average remaining lease term (years) Segment Reporting Information [Line Items] Reverse stock split ratio Stockholders' Equity Note, Stock Split, Conversion Ratio Reverse stock split ratio Stock Issued During Period, Shares, Restricted Stock Award, Gross Vesting of restricted common stock, Shares Lease, Cost Total License Agreement Terms License Agreement Terms [Member] Derivative Liability, Fair Value, Gross Liability, Total Derivative Liability, Subject to Master Netting Arrangement, before Offset Success payment liability Letter of Credit Letter of Credit [Member] Product Development and Regulatory Approval Product Development and Regulatory Approval [Member] Product Development and Regulatory Approval. Fair value of equity instruments issued Business Combination, Consideration Transferred, Equity Interest Derivative Liability, Current Current portion of derivative liabilities Property, Plant and Equipment, Net, Ending Balance Property, Plant and Equipment, Net, Beginning Balance Property, Plant and Equipment, Net Property and equipment, net Property and equipment, net Contingent consideration liability milestones Contingent Consideration Liability Milestones [Member] Contingent consideration liability milestones. Contingent Consideration Liability Milestones Loss from operations Operating Income (Loss) Retained Earnings [Member] Accumulated Deficit Business Combination, Contingent Consideration, Type [Domain] Share-based Payment Arrangement, Noncash Expense, Total Share-Based Payment Arrangement, Noncash Expense Stock-based compensation expense Measurement Input, Price Volatility [Member] Expected Volatility Volatility of Market Participants Payments of Stock Issuance Costs Payment of initial and follow-on public offering costs Payment of equity offering costs Senior Secured Term Loan Tranche Five [Member] Senior Secured Term Loan Tranche Five. Computer equipment and software. Computer Equipment And Software [Member] Computer Equipment and Software Reduction in employee headcount, positions Restructuring and Related Cost, Number of Positions Eliminated Operating Lease, Weighted Average Discount Rate, Percent Weighted-average discount rate Operating Lease, Liability, Noncurrent Long-term lease liability Fair Value, Inputs, Level 1 [Member] Level 1 Market capitalization Debt Instrument Market Capitalization Value Debt instrument market capitalization value. Class of Stock [Line Items] Class Of Stock [Line Items] Net cash provided by (used in) financing activities Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Lease, Cost [Table Text Block] Summary of Operating Lease Costs Non-taxable or non-deductible items: Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent [Abstract] Change in Accounting Principle, Accounting Standards Update, Adopted [true false] Change in Accounting Principle, Accounting Standards Update, Adopted Auditor Location Derivative Liability, Noncurrent Long-term portion of derivative liabilities Finance lease liability payments. Finance Lease Liability Payments [Line Items] Finance Lease Liability Payments [Line Items] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Schedule of Potential Common Shares Excluded from Computation of Diluted Net Loss per Share Corporate Debt Securities [Member] Corporate Notes Income Tax Jurisdiction [Domain] Income Tax Authority Debt Securities, Available-for-Sale [Table] Entity Interactive Data Current Entity Interactive Data Current Deferred revenue Increase (Decrease) in Contract with Customer, Liability Statement of Income Location, Balance [Domain] Income Statement Location Consideration of Technology Liabilities Technology Milestones Contingent Consideration Of Technology Liabilities [Member] Contingent consideration of technology liabilities. Fair Value Measurement [Domain] Fair Value Measurement Operating activities Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] Furniture and Fixtures [Member] Furniture and Fixtures Convertible Preferred Stock, Shares Issued upon Conversion Shares issued upon conversion of preferred stock Common stock issuable upon conversion Upfront payment received under term of agreement Upfront Payment Received Under Term of Agreement The amount of upfront payment received under the terms of an agreement. 162(m) related deductions Effective Income Tax Rate Reconciliation Nondeductible Expense 162 m Related Deductions Effective income tax rate reconciliation nondeductible expense 162 m related deductions. Harvard Harvard license agreement. Harvard License Agreement [Member] Harvard Business Combination, Consideration Transferred, Equity Interest, Share Issued, Number of Shares Upfront payment, shares Increase (Decrease) in Other Noncurrent Liabilities Other long-term liabilities Commencement of first phase of lease in October 2020. Commencement Of First Phase Of Lease In October Twenty Twenty [Member] First Phase of Lease in October 2020 Terry-Ann Burrell [Member] Terry-Ann Burrell Terry-Ann Burrell Cumulative Effect, Period of Adoption [Domain] Entity Tax Identification Number Entity Tax Identification Number Upfront fee receivable upon signing contract The amount of upfront fee receivable upon signing of a collaboration agreement. Strategic Financing Agreement [Member] Strategic financing agreement. Strategic Financing Agreement [Member] Debt Instrument, Term Debt instrument term Maturities of marketable securities Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale Number of common stock received The number of shares of stock received as part of a collaboration and license agreement. Collaboration License Agreement Shares Received Local Phone Number Local Phone Number Related Party Transaction [Domain] Related Party Transaction Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount Unrecognized compensation cost related to unvested stock options Short-Term Lease, Cost Short-term lease costs Weighted Average Number of Shares Outstanding, Diluted [Abstract] Denominator: Auditor Opinion [Text Block] Auditor Opinion Finance Lease, Liability, to be Paid, Year Two 2024 Net cash acquired from Guide Cash Acquired from Acquisition Accounting Policies [Abstract] Amount upon achievement of milestone Amount Upon Achievement Of Milestone The amount the Company is eligible to borrow, per tranche, upon achievement of specified milestones, as part of a financing arrangement. Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from amortization. Deferred Tax Assets Amortization Amortization License and collaboration revenue Revenue from Contract with Customer, Excluding Assessed Tax Revenue from Contract with Customer, Excluding Assessed Tax, Total Revenue Corporate Equity Securities [Member] Corporate Equity Securities Corporate equity securities. Net Income (Loss) Attributable to Parent [Abstract] Numerator: Regulatory Regulatory [Member] Regulatory Lessee, Operating Lease, Liability, to be Paid, Year Four 2029 The amount of outstanding common stock held by the Company as part of a license and collaboration agreement, as a percentage. License and Collaboration Agreement Outstanding Common Stock Held Percentage License and collaboration agreement outstanding common stock held percentage Class of Stock [Domain] Class of Stock Commercial Paper [Member] Commercial Paper Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Number of shares available for future issuance Unrecognized compensation cost, cost to recognize over a weighted-average period Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Accrued Professional Fees, Current Professional fees Cash, Cash Equivalents, and Short-term Investments, Total Cash, Cash Equivalents, and Short-Term Investments Cash, cash equivalents, and marketable securities Stock sold during period shares, new issues Number of new shares sold, but not necessarily issued, during the period. Stock Sold During Period Shares, New Issues Shares issued and sold Stock, Class of Stock [Table] Schedule Of Stock By Class [Table] Other Operating Income Expense. Other Operating Income Expense [Abstract] Other income (expense): Entity Emerging Growth Company Entity Emerging Growth Company Indefinite-Lived Intangible Assets [Axis] Success Payment Liabilities Success Payment Liabilities [Member] Success payment liabilities. Total transaction price Business Combination, Recognized Asset Acquired to Liability Assumed, Excess (Less), and Goodwill John Evans Chief Executive Officer. John Evans Chief Executive Officer [Member]