Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Maximum
Expected volatility
Impairment, Long-Lived Asset, Held-for-Use, Total
Impairment Of Long Lived Assets Held For Use
Impairment of long-lived assets
Lessee operating lease, description
Lessee, Operating Lease, Description
Business combination upfront consideration paid in common stock
The aggregate amount of consideration paid to former stockholders and optionholders in common stock, as part of a business combination, excluding purchase price adjustments.
Business Combination Upfront Consideration paid in Common Stock
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Vesting period
Contingent Consideration by Type [Axis]
Segment Reporting Policy Policy [Text Block]
Segment and Geographic Information
Prime medicine Inc.
Prime Medicine Inc [Member]
Prime Medicine Inc
Operating Loss Carryforwards, Total
Operating Loss Carryforwards
Net operating loss carryforwards
Milestone liabilities projected year of achievement
The year in which achievement is expected to be attained for contingent consideration liability milestones.
Business Combination Contingent Consideration Liability Expected Achievement Year
Forecast
Forecast [Member]
Auditor Location
Operating Expenses [Abstract]
Operating expenses:
Finite-Lived Intangible Assets by Major Class [Axis]
Temporary Equity Accretion To Redemption Value Adjustment
Accretion of redeemable convertible preferred stock to redemption value, including dividends on preferred stock
Accretion of redeemable convertible preferred stock to redemption value, including dividends on preferred stock
Sana Biotechnology
Sana Biotechnology.
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain]
Asset Class
Operating Income Loss
Loss from operations
Operating lease liabilities
Increase (Decrease) in Operating Lease Liability
Collaboration agreement first anniversary amount receivable
Collaboration Agreement First Anniversary Amount Receivable
The amount receivable on the one-year anniversary of the signing date of a collaboration agreement.
Upfront payment fair value shares received
Upfront Payment Fair Value Shares Received
The fair value of shares received as an upfront payment as part of license agreement.
Entity Emerging Growth Company
Entity Emerging Growth Company
Reimbursed Costs
Reimbursed Costs [Member]
Income Tax Disclosure [Abstract]
Financial Instrument [Axis]
Financial Instrument
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Increase Decrease In Prepaid Deferred Expense And Other Assets
Prepaid expenses and other current assets
Canceled
Canceled
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Schedule Of Cash And Cash Equivalents Table [Text Block]
Reconciliation of Cash, Cash Equivalents, and Restricted Cash
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Number of shares available for future issuance
Marketable Securities Policy
Marketable Securities
Payments to Acquire Property, Plant, and Equipment, Total
Payments To Acquire Property Plant And Equipment
Purchases of property and equipment
Statement Geographical [Axis]
Geographical
Common stock, value
Common stock, $0.01 par value; 250,000,000 shares authorized, 68,581,251 and 58,446,016 issued, and 68,389,425 and 57,254,178 outstanding at December 31, 2021 and 2020, respectively
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Milestone payment value of stock issued
Entity Address State Or Province
Entity Address, State or Province
Liabilities
Total liabilities
At-The-Market
At The Market [Member]
At-The-Market .
Unrealized (loss) gain on marketable securities
Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent
Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent, Total
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Weighted-average risk-free interest rate
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
The interest rate on finance leases.
Finance Lease Liability Payments Interest Percentage
Finance lease liability payments interest percentage
Reverse stock split
Stockholders' Equity, Reverse Stock Split
Pfizer Inc
Pfizer Inc [Member]
Amount of increase (decrease) in the fair value of contingent consideration recognized in the income statement.
Change In Fair Value Of Contingent Consideration Liabilities
Change in fair value of contingent consideration liabilities
Change in fair value of contingent consideration liabilities
Equity securities, Fair Value
Equity securities, Amortized Cost
Equity securities included in marketable securities
Equity securities
Class Of Stock [Domain]
Class of Stock
Sublease income
Sublease Income
Sublease income
License Agreement Terms
License Agreement Terms [Member]
Convertible Preferred Stock Shares Issued Upon Conversion
Shares issued upon conversion of preferred stock
Common stock issuable upon conversion
Bio Palette Patent.
Bio Palette Patent [Member]
Bio Palette Patent
Unrealized gains on investment
Equity Securities, FV-NI, Unrealized Gain (Loss)
Equity Securities, FV-NI, Unrealized Gain (Loss), Total
Temporary Equity Accretion To Redemption Value
Accretion of redeemable convertible preferred stock to redemption value
Business Combinations [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding [Roll Forward]
Number of options
Property Plant And Equipment Estimated Useful Lives
Property and equipment, estimated useful life
Redeemable Convertible Preferred Stock [Member]
Redeemable Convertible Preferred Stock
Merger agreement description
Noncash or Part Noncash Acquisition, Description
Business Acquisition [Line Items]
Deferred Tax Liabilities Property Plant And Equipment
Property and equipment
Legal Entity [Axis]
Legal Entity
Defined Contribution Plan Employer Discretionary Contribution Amount
Employer matching contribution to 401(k)
Increase (decrease) in financing milestone liabilities.
Increase Decrease In Financing Milestone Liabilities
Financing milestone liabilities
General And Administrative Expense [Member]
General and Administrative
Total transaction price
Business Combination, Recognized Identifiable Assets Acquired, Goodwill, and Liabilities Assumed, Net
Exercisable as of December 31, 2021
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Harvard Institute
Harvard Institute [Member]
Harvard Institute.
Square feet of office and laboratory space
The amount of area rented under an operating lease, in square feet.
Area of Rented Space
Contingent consideration liability measurement input
Business Combination, Contingent Consideration, Liability, Measurement Input
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Amount of investment in debt and equity securities measured at fair value (available-for-sale).
Marketable securities held, Fair Value
Available For Sale Debt Securities and Equity Securities FV-Ni
Schedule Of Related Party Transactions By Related Party [Table]
Schedule Of Related Party Transactions By Related Party [Table]
Scientific founders.
Scientific Founders [Member]
Scientific Founders
City Area Code
City Area Code
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions Table [Text Block]
Schedule of Assumptions Used in Black-Scholes Option-Pricing Model for Stock Options Granted
Deferred Tax Assets Gross
Total deferred tax assets
Number of operating lease renewal options.
Number Of Operating Lease Renewal Options
Operating lease, number of renewal options
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value [Roll Forward]
Weighted-average grant date fair value
U S Treasury Securities [Member]
U.S. Treasury Securities
Change In Accounting Principle Accounting Standards Update Adopted
Change in Accounting Principle, Accounting Standards Update, Adopted
Share Based Compensation Arrangements By Share Based Payment Award Options Forfeitures In Period Weighted Average Exercise Price
Forfeitures
Deferred revenue liability
Contract with Customer, Liability
Contract with Customer, Liability, Total
Commitments and contingencies (See Note 7, Leases, Note 9, License agreements and Note 10, Collaboration and license agreements)
Commitments And Contingencies
Share based compensation arrangement by share based payment award aggregate intrinsic value.
Share Based Compensation Arrangement By Share Based Payment Award Aggregate Intrinsic Value [Abstract]
Aggregate intrinsic value
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Schedule of Potential Common Shares Excluded from Computation of Diluted Net Loss per Share
Shares issued and sold
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs, Shares
Number of common stock issued
Available-for-sale, Fair Value
Marketable securities
Debt Securities, Available-for-sale, Total
Scenario [Axis]
Guide Acquisition
Business Combination Disclosure [Text Block]
Additional success payment amount due
Additional Success Payment Amount Due
Additional success payment amount due.
Operating lease, termination month and year.
Operating Lease Termination Month And Year
Operating lease, termination month and year
Basis Of Accounting Policy Policy [Text Block]
Basis of Presentation
Liabilities Fair Value Disclosure [Abstract]
Liabilities
Total liabilities
Liabilities Fair Value Disclosure
Total liabilities
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents
Cash, cash equivalents and restricted cash—end of period
Cash, cash equivalents and restricted cash—beginning of period
Total cash, cash equivalents, and restricted cash
Transaction price allocated to each of six performance obligations
Transaction Price Allocated to Each Performance Obligations
Transaction price allocated to each performance obligations.
Related Party [Domain]
Related Party
The amount of milestones the Company may be eligible to receive.
Development regulatory and commercial milestones receivable
Development Regulatory and Commercial Milestones Receivable
Stock Issued During Period Value Conversion Of Convertible Securities
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering
Other, net
Other Noncash Income (Expense), Total
Other Noncash Income Expense
Income Statement [Abstract]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Collaborative Arrangement Nature And Purpose
Agreement description
Finance Lease Liability Maturity Table [Text Block]
Summary of Future Minimum Payments Related to Equipment Financing Obligations
Assigned to Company
Assigned to Company [Member]
Assigned to company.
Payment of upfront fee.
Payment Of Upfront Fee
Upfront fee paid
Net cash used in investing activities
Net Cash Provided By Used In Investing Activities
Capital Expenditures Incurred But Not Yet Paid
Property and equipment additions in accounts payable and accrued expenses
Office and laboratory space.
Office And Laboratory Space [Member]
Office and Laboratory Space
Employee-related Liabilities, Current, Total
Employee Related Liabilities Current
Employee compensation and related benefits
Schedule of Assumptions Used in Black-Scholes Option Valuation Model to Estimate Fair Value of Purchase Right Under ESPP
Schedule of Share-based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block]
General and Administrative Expense, Total
General And Administrative Expense
General and administrative
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property Plant And Equipment Net
Property and equipment, net
Property and equipment, net
Current portion of deferred revenue
Contract with Customer, Liability, Current
Common Stock, Shares, Issued, Total
Common Stock Shares Issued
Common stock, shares issued
Milestone payment shares issued
Annual percentage increase in shares authorized
Share Based Compensation Arrangement By Share Based Payment Award Annual Increase Percentage
The automatic increase in the number of shares that may be issued under a share-based payment arrangement on the first day of each fiscal year, as a percentage of shares outstanding.
Canceled
Canceled
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Intangible assets
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles
Available-for-sale, Amortized Cost
Debt Securities, Available-for-sale, Amortized Cost
Operating Lease Right Of Use Asset
Operating lease right-of-use assets
The period over which performance obligations are expected to be recognized.
Revenue program performance obligation period
Revenue Program Performance Obligation Period
Security Exchange Name
Security Exchange Name
Range [Member]
Statistical Measurement
Derivative Term Of Contract
Success payment liability, term
Furniture And Fixtures [Member]
Furniture and Fixtures
Operating lease, termination date
Operating lease termination date.
Operating Lease Termination Date
Net Income Loss Available To Common Stockholders Basic
Net loss attributable to common stockholders
Collaboration agreement first anniversary amount due
The amount due on the one-year anniversary of the signing date of a collaboration agreement.
Collaboration Agreement First Anniversary Amount Due
Cash acquired
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash and Equivalents
Other Liabilities, Noncurrent, Total
Other Liabilities Noncurrent
Other liabilities
Measurement Input Price Volatility [Member]
Expected Volatility
Cash And Cash Equivalents Fair Value Disclosure
Cash equivalents
Freestanding Financial Instruments and Derivatives
Derivatives, Policy [Policy Text Block]
Subsequent Event Type [Domain]
Subsequent Event Type
Document Period End Date
Document Period End Date
Manufacturing Facility [Member]
Manufacturing Facility
Restricted Cash Noncurrent
Restricted cash
Income Statement Location [Axis]
Income Statement Location
MASSACHUSETTS
Massachusetts
Collaboration agreement performance obligation revenue recognized
The amount of revenue recognized during the period for satisfaction of performance obligations as part of a collaboration agreement.
Collaboration Agreement Performance Obligation Revenue Recognized
Related Party Transaction [Axis]
Related Party Transaction
Common Stock Shares Authorized
Common stock, shares authorized
Use Of Estimates
Use of Estimates
Operating Lease Liability Current
Current portion of lease liability
Related Party Transactions By Related Party [Axis]
Related Party
Contract asset
Contract with Customer, Asset, after Allowance for Credit Loss
Contract with Customer, Asset, after Allowance for Credit Loss, Total
Supplemental Cash Flow Information [Abstract]
Supplemental disclosure of cash flow information:
Statement Class Of Stock [Axis]
Class of Stock
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
The amount of expense incurred for non-royalty sublicense fees owed to licensor.
Non-royalty sublicense fees owed
Non Royalty Sublicense Fees Owed
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Antidilutive shares excluded from computation of diluted net loss per share
Nonrefundable upfront payment receivable
Nonrefundable upfront payment receivable.
Gross proceeds from issuance of common stock
Gross Proceeds From Issuance Of Common Stock
Gross proceeds from issuance of common stock.
Performance-based stock options.
Performance Based Stock Options [Member]
Performance-based Stock Options
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Stock options
Cash paid for interest
Interest Paid, Excluding Capitalized Interest, Operating Activities
Effective Income Tax Rate Continuing Operations
Total
Schedule Of Fair Value Assets And Liabilities Measured On Recurring Basis Table [Text Block]
Schedule of Fair Value of Financial Assets and Liabilities
Current Fiscal Year End Date
Current Fiscal Year End Date
Net increase (decrease) in cash, cash equivalents and restricted cash
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
Portion at Fair Value Measurement [Member] [Default]
Portion At Fair Value Fair Value Disclosure [Member]
Fair Value Disclosure Item Amounts [Default]
Related Party Transaction Purchases From Related Party
Purchases from related party
Operating Lease Cost
Operating lease costs
Finance Lease Liability Payments Due
Total
Finance lease annual rent
Finance Lease Annual Rent
The annual rent amount under a financing lease.
Second Phase of Lease in January 2021
Commencement Of Second Phase Of Lease In January Two Thousand Twenty One [Member]
Commencement of second phase of lease in January two thousand twenty one.
Lessee Operating Lease Existence Of Option To Extend
Operating lease, existence of option to extend
IRS
Internal Revenue Service (IRS) [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques [Table]
Counterparty Name [Axis]
Assets [Abstract]
Assets
Operating lease, amendment month and year.
Operating Lease Amendment Month And Year
Operating lease, amendment month and year
Income Tax Authority, Name [Domain]
Stock Issued During Period Shares Conversion Of Convertible Securities
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering, Shares
Assets Fair Value Disclosure [Abstract]
Assets
Estimate Of Fair Value Fair Value Disclosure [Member]
Fair Value
Property and equipment
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment, Total
2022
Lessee Operating Lease Liability Payments Due Next Twelve Months
Accounts Payable, Current, Total
Accounts Payable Current
Accounts payable
U S Government Agencies Debt Securities [Member]
Government Securities
Private Placement [Member]
Private Placement
Common Stock Par Or Stated Value Per Share
Common stock, par or stated value per share
Contract Balances
Revenue from Contract with Customer [Policy Text Block]
Effective Income Tax Rate Reconciliation Tax Credits Research
Research and development tax credits
Potential milestone payable in form of common stock
The amount of potential milestones payable in the form of common stock as part of a business combination.
Potential Milestone Payable In Form Of Common Stock
State And Local Jurisdiction [Member]
State
Weighted average number of common shares, basic
Weighted-average common shares used in net loss per share attributable to common stockholders, basic
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Shares Outstanding
Ending Balance, Shares
Beginning Balance, Shares
Investments Debt And Equity Securities [Abstract]
Including 2017 Plan Shares
Including Two Thousand Seventeen Plan Shares [Member]
Including Two Thousand Seventeen Plan Shares [Member]
Tabular disclosure of the success payment liability arising from a licensing agreement.
Schedule Of Success Payment Liability Table [Text Block]
Schedule of Success Payment Liability
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
The anticipated amount of undiscounted lease payments that will be due under a lease that has not yet begun.
Lessee Operating Lease Lease Not Yet Commenced Anticipated Undiscounted Lease Payments Due
Lessee, operating lease, lease not yet commenced anticipated undiscounted lease payments due
Research And Development Expense Policy
Research and Development Costs
Fair Value by Liability Class [Domain]
Broad License Agreement
Broad license agreement.
Broad License Agreement [Member]
Broad Institute
Earliest Tax Year
Earliest Tax Year [Member]
Document Type
Document Type
Investments In Debt And Marketable Equity Securities And Certain Trading Assets Disclosure [Text Block]
Marketable Securities
Number of shares of new stock classified as temporary equity issued during the period.
Temporary Equity Stock Issued During Period Shares New Issues
Issuance of Series B redeemable convertible preferred stock, net of issuance costs of $95, Shares
Domestic Country [Member]
Federal
Total transaction price
Business Combination, Consideration Transferred
Preferred stock, $0.01 par value; 25,000,000 and no shares authorized, and no shares issued or outstanding at December 31, 2021 and 2020, respectively
Preferred Stock, Value, Issued, Ending Balance
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Total
Preferred Stock Value
Finance Lease Interest Expense
Payment of interest
Operating Lease Liability Noncurrent
Long-term lease liability
Schedule of Accrued Expenses and Other Current Liabilities
Schedule of Accrued Liabilities [Table Text Block]
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Amount of increase (decrease) in the fair value of derivative liabilities.
Change In Fair Value Of Derivative Liabilities
Change in fair value of derivative liabilities
Assets Current
Total current assets
Liability Class [Axis]
Success Payments
Success Payments [Member]
Success Payments.
License agreement description
Research and Development Arrangement, Contract to Perform for Others, Description and Terms
Summary of Depreciation Expense Incurred
Tabular disclosure of depreciation expense related to physical assets used in the normal conduct of business and not intended for resale.
Summary Of Depreciation Expense Incurred Table Text Block
Outstanding Options to Purchase Common Stock
Stock Options
Unvested Stock Options
stock options and restricted stock.
Stock Options And Restricted Stock [Member]
Stock Options and Restricted Stock
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Outstanding as of December 31, 2020
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Income Tax Expense (Benefit), Total
Income Tax Expense Benefit
Income tax expense
Cash Flow Noncash Investing And Financing Activities Disclosure [Abstract]
Supplemental disclosure of non-cash investing and financing activities:
Pfizer
Pfizer [Member]
Pfizer.
Number of shares issued during the period upon vesting of restricted common stock.
Stock Issued During Period Shares Vesting Of Restricted Common Stock
Vesting of restricted common stock, Shares
Number of shares issued for upfront payment of acquisition
Number Of Shares Issued For Upfront Payment Of Acquisition
Number of shares issued for upfront payment of acquisition.
2026
Finance Lease, Liability, to be Paid, Year Five
Leases [Abstract]
ASU 2017-01
Accounting Standard Update 201701 [Member]
Accounting standard update 201701.
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities
Income Tax Credits And Adjustments
Tax credits
Consolidation Policy [Text Block]
Principles of Consolidation
Fair Value By Measurement Basis [Axis]
Measurement Basis
Unvested as of December 31, 2021
Unvested as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Summary of Transaction Price Determined and Allocated
Schedule of Business Acquisitions, by Acquisition [Table Text Block]
Deferred Tax Assets, Operating Loss Carryforwards, Total
Deferred Tax Assets Operating Loss Carryforwards
Net operating loss carryforwards
Stock Issued1
Issuance of common stock for research and development licenses
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock Shares Outstanding
Common stock, shares outstanding
Plan Name [Axis]
Plan Name
The value of stock converted upon the conversion of convertible securities.
Temporary Equity Conversion Of Redeemable Convertible Preferred Stock To Common Stock Upon Closing Of Initial Public Offering Value
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Less accumulated depreciation
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Forfeitures
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
The percentage of net profits and development and commercialization costs assigned to the specified party.
Net profits as well as development and commercialization costs percentage
Net Profits and Development and Commercialization Costs Percentage
Shares issued and sold
Sale Of Stock Consideration Received On Transaction
Net proceeds from sale of common stock
The value of common stock received in exchange for a technology license.
Receipt Of Common Stock In Exchange For Technology License
Receipt of common stock in exchange for technology license
Revenue Recognition Policy [Text Block]
Revenue Recognition
The amount of success payments payable upon achievement of specified stock value targets.
Success Payments
Success payments
Milestone payment method, description
Business Combination, Contingent Consideration Arrangements, Description
Number of shares issued during the period related to a license agreement.
Issuance Of Common Stock Shares Related To License Agreement
Issuance of common stock related to license agreement, Shares
Nature of the business and basis of presentation.
Nature Of Business And Basis Of Presentation [Table]
Nature Of Business And Basis Of Presentation [Table]
Operating Expenses
Total operating expenses
The minimum exercise price per share of stock options, as a percentage of the fair market value of common stock on the date of grant.
Share Based Compensation Arrangement By Share Based Payment Award Percentage Of Exercise Price Per Share Of Stock Options On Fair Market Value Of Common Stock
Percentage of exercise price per share of stock options on fair market value of common stock
I P O [Member]
IPO
Lease Cost
Total
Weighted Average Number Of Shares Outstanding [Abstract]
Denominator:
Transfers And Servicing Of Financial Instruments Types Of Financial Instruments [Domain]
Financial Instruments
Collaboration agreement upfront payment received
The amount of upfront payment received as part of a collaboration agreement.
Collaboration Agreement Upfront Payment Received
Available-for-sale, Gross Unrealized Losses
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Obligation to issue common stock shares
The number of shares of stock the Collaborator is obligated to issue to the Company if the Company elects to extend the collaboration.
Obligation to Issue Common Stock Shares
Weighted-average exercise price
Outstanding as of December 31, 2021
Outstanding as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Net Cash Provided By Used In Operating Activities [Abstract]
Operating activities
In-process research and development charge
Research and development expense
Research and Development in Process
Contingent consideration liabilities assumed in asset acquisition
Noncash or Part Noncash Acquisition, Value of Liabilities Assumed
Noncash or Part Noncash Acquisition, Value of Liabilities Assumed, Total
Deferred Tax Liabilities Other
Other
Transaction price
Business Combination Transaction Price [Abstract]
Business combination transaction price.
Lessee Operating Lease Liability Maturity Table [Text Block]
Summary of Future Minimum Lease Payments of Operating Leases
Operating Loss Carryforwards [Table]
Operating Loss Carryforwards [Table]
Collaboration arrangement extension term
Collaboration arrangement extension term.
Collaboration Arrangement Extension Term
Net loss per common share attributable to common stockholders, diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Payment of milestone amount.
Payment Of Milestone Amount
Milestone payment paid
Available-for-sale, Gross Unrealized Gains
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
Earnings Per Share [Abstract]
Fair value of equity instruments issued in connection with asset acquisition
Fair Value Of Equity Instruments Issued In Connection With Asset Acquisition
Fair value of equity instruments issued in connection with asset acquisition.
Share Based Compensation Arrangement By Share Based Payment Award Description
Common stock, shares description
Business Acquisition, merger agreement date
Business Acquisition, Date of Acquisition Agreement
Apellis Pharmaceuticals, Inc
Apellis Pharmaceuticals, Inc.
Apellis Pharmaceuticals Inc [Member]
2023
Lessee Operating Lease Liability Payments Due Year Two
Net Income Loss
Net loss
Net loss
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Schedule of Reconciliation of Income Tax Expense
Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block]
Accrued Expenses and Other Current Liabilities
Concentration Risk Credit Risk
Concentrations of Credit Risk
Compensation And Employee Benefit Plans [Text Block]
Employee Benefits
Operating Lease Weighted Average Discount Rate Percent
Weighted-average discount rate
Research And Development Expense [Member]
Research and Development
Research and Development Expense
Document Fiscal Period Focus
Document Fiscal Period Focus
Temporary Equity Stock Issued During Period Value New Issues
Issuance of Series B redeemable convertible preferred stock, net of issuance costs of $95
Number of founder shareholders.
Number Of Founder Shareholders
Number of founder shareholders
Jeffries LLC Amended Sales Agreement
Jeffries LLC amended sales agreement.
Jeffries LLC Amended Sales Agreement [Member]
Accounting Policies [Abstract]
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income Loss Net Of Tax
Accumulated other comprehensive (loss) income
Carrying value as of the balance sheet date of obligations incurred through that date and payable for process development and manufacturing costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Accrued Process Development And Manufacturing Costs
Process development and manufacturing costs
Entity Address Address Line1
Entity Address, Address Line One
Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
Aggregate intrinsic value of stock options exercised
Outstanding as of December 31, 2021
Outstanding as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Contingent Consideration Liabilities
Contingent Consideration Liabilities [Member]
Contingent consideration liabilities.
Disclosure of accounting policy for equity issuance costs.
Equity Issuance Costs Policies Policy [Text Block]
Equity Issuance Costs
Liabilities Current
Total current liabilities
The number of shares converted upon the conversion of convertible securities.
Temporary Equity Conversion Of Redeemable Convertible Preferred Stock To Common Stock Upon Closing Of Initial Public Offering Shares
Conversion of redeemable convertible preferred stock to common stock upon closing of initial public offering, Shares
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Profit Loss
Net loss
Commercial Paper [Member]
Commercial Paper
Upon Participation Election
Upon Participation Election [Member]
Upon participation election.
Entity Address Postal Zip Code
Entity Address, Postal Zip Code
Amount of increase (decrease) in operating lease right-of-use assets.
Change In Operating Lease Right Of Use Assets
Change in operating lease right-of-use assets
Employees, officers, board of directors and consultants
Employees Officers Board Of Directors And Consultants [Member]
Employees, Officers, Board of Directors and Consultants
Title Of Individual [Axis]
Title of Individual
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Outstanding
Lessee Operating Lease Liability Payments Due
Total undiscounted lease payments
Products And Services [Domain]
Product and Service
Redeemable convertible preferred stock (See Note 11, Redeemable convertible preferred stock)
Temporary Equity Carrying Amount Attributable To Parent
Redeemable convertible preferred stock, Ending Balance
Redeemable convertible preferred stock, Beginning Balance
Additional fee per additional option right
Additional Fee Per Additional Option Right
The amount of fee per additional option right.
Change in fair value of equity investments
Change in fair value of non-controlling equity investments
Change in fair value of non-controlling equity investments
Equity securities recognition amount
Equity Securities, FV-NI, Gain (Loss), Total
Other liabilities assumed
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Noncurrent Liabilities, Other
Proceeds From Issuance Initial Public Offering
Proceeds from public offering, net of underwriting discount
Gross proceeds from sale of common stock
Equipment [Member]
Equipment
Arrangements And Nonarrangement Transactions [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Net Cash Provided By Used In Operating Activities
Net cash used in operating activities
Operating lease, commencement month and year.
Operating Lease Commencement Month And Year
Operating lease, commencement month and year
Increase Decrease In Other Noncurrent Liabilities
Other long-term liabilities
Statement Equity Components [Axis]
Equity Components
Common stock, offering period, start date
The commencement date of the first offering period of a share based payment plan, in YYYY-MM-DD format.
Share Based Compensation Arrangement By Share Based Payment Award Offering Period Start Date
Lease Cost Table [Text Block]
Summary of Operating Lease Costs
Tax Period [Axis]
Assets Current [Abstract]
Current assets:
Variable Lease Cost
Variable lease costs
Entity Registrant Name
Entity Registrant Name
Finance Lease, Liability, Total
Finance Lease Liability
Financing obligations
Amount, before tax, of unrealized loss on investment in debt and equity securities measured at fair value (available-for-sale).
Marketable securities held, Gross Unrealized Losses
Available For Sale Debt Securities and Equity Securities FV-Ni Accumulated Gross Unrealized Loss Before Taxes
Series A Preferred Stock [Member]
Series A Preferred Stock
Series A Preferred Stock Shares
Stockholders Equity Note Disclosure [Text Block]
Preferred and Common Stock
Contractual maturity dates of investments
Describes the period of time in which investments will reach maturity.
Debt Securities, Available-for-sale, Maturity Period
Entity Interactive Data Current
Entity Interactive Data Current
Entity Address City Or Town
Entity Address, City or Town
Equity issuance costs in accounts payable and accrued expenses.
Equity Issuance Costs In Accounts Payable And Accrued Expenses
Equity issuance costs in accounts payable and accrued expenses
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate Minimum
Expected volatility
Measurement Input Expected Term [Member]
Expected Term (years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Expected term (in years)
Trading Symbol
Trading Symbol
Schedule of Variables Included in Calculation of Estimated Fair Value
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
Stock issuance costs
Costs incurred in a stock issuance transaction.
Stock Issuance Costs
Net Cash Provided By Used In Investing Activities [Abstract]
Investing activities
Lessee Operating Lease Liability Undiscounted Excess Amount
Less: imputed interest
Reconciliation of net loss to net gain (loss) attributable to common stockholders.
Reconciliation Of Net Gain Loss To Net Loss Attributable To Common Stockholders [Abstract]
Reconciliation of net loss to net loss attributable to common stockholders:
Local Phone Number
Local Phone Number
Series B redeemable convertible preferred stock.
Series B Redeemable Convertible Preferred Stock [Member]
Series B Redeemable Convertible Preferred Stock
Lab equipment.
Lab Equipment [Member]
Lab Equipment
ASU 2016-02
Accounting Standards Update 2016-02 [Member]
Total stockholders' equity
Stockholders Equity
Ending Balance
Beginning Balance
Subsequent Event Type [Axis]
Subsequent Event Type
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price [Roll Forward]
Weighted average exercise price
Operating Lease Payments
Operating cash flows used for operating leases
Comprehensive Income Policy Policy [Text Block]
Comprehensive Loss
License agreement upfront payment received
License Agreement Upfront Payment Received
The amount received as upfront payment under a license agreement.
Preferred Stock, Shares Issued, Total
Preferred Stock Shares Issued
Preferred stock, shares issued
Total assets
Assets Fair Value Disclosure
Total Assets
Collaboration receivable
Amounts due as part of a collaboration agreement, due within 1 year (or 1 business cycle).
Collaboration Receivable Current
Range [Axis]
Statistical Measurement
Entity Small Business
Entity Small Business
Purchases of marketable securities
Payments to Acquire Debt Securities, Available-for-sale
Common Stock Received
Common stock received.
Sublease, commencement month and year
The month and year in which a sublease will commence.
Sublease Commencement Month and Year
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock Shares Outstanding
Preferred stock, shares outstanding
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Lessee Leases Policy [Text Block]
Leases and Rent Expense
Verve Therapeutics, Inc.
Verve Therapeutics Inc [Member]
Verve Therapeutics, Inc.
Fair Value Measurements Fair Value Hierarchy [Domain]
Fair Value Hierarchy and NAV
The amount of commercial milestone payments or royalties due.
Commercial Milestone Payments Or Royalties Due
Commercial milestone payments or royalties due
Stock-based compensation
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Over Allotment Option [Member]
Underwriters Option
Credit Facility [Axis]
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Schedule of Components of Deferred Taxes
Alexandria Real Estate Equities, Inc.
Alexandria Real Estate Equities Inc [Member]
Alexandria Real Estate Equities, Inc.
Impairment Or Disposal Of Long Lived Assets Policy [Text Block]
Impairment of Long-Lived Assets
Common Stock Voting Rights
Common stock, voting rights
Income tax examination, year under examination
Income Tax Examination, Year under Examination
Property Plant And Equipment Useful Life
Property and equipment, estimated useful life
Finance Lease Liability Undiscounted Excess Amount
Less: amounts representing interest at 8.76%
Entity [Domain]
Entity
Amount of noncash research and development expense for licensing agreements.
Non-cash research and development license expense, net
Non Cash Research And Development License Expense
Business Acquisition [Axis]
Business Acquisition
ASC 606
Accounting Standards Update 2014-09 [Member]
Jeffries LLC Sales Agreement
Jeffries LLC sales agreement.
Jeffries LLC Sales Agreement [Member]
Balance Sheet Location [Axis]
Balance Sheet Location
The valuation multiple applied to the initial weighted average of the specified class of stock, used to determine success payment targets.
Success Payments Valuation Multiples
Success Payments, valuation multiples
Upfront revenue recognized
The amount of upfront revenue recognized.
Upfront Revenue Recognized
Number of shares issued
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period
Defined Contribution Plan Employer Matching Contribution Percent Of Match
Employer matching contribution to 401(k) Plan as a percentage of employee's contribution
Guide Therapeutics, Incorporated.
Guide Therapeutics Incorporated [Member]
Guide Therapeutics, Inc.
Research costs
Carrying value as of the balance sheet date of obligations incurred through that date and payable for research costs. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).
Accrued Research Costs
Additional Paid in Capital, Ending Balance
Additional Paid in Capital, Beginning Balance
Additional Paid in Capital, Total
Additional Paid In Capital
Additional paid-in capital
Earn-out payment period
Earnout Payment Period
Earn-out payment period.
Defined contribution plan name
Defined Contribution Plan Name
Defined contribution plan name.
Summary of Marketable Securities Held
Schedule of Available-for-sale Securities Reconciliation [Table Text Block]
Payments received from (made to) related parties
Related Party Transaction Amounts Of Transaction
Fair value of common stock issued to settle success payment liability
Fair Value Of Common Stock Issued To Settle Success Payment Liability
The fair value of common stock issued to satisfy a success payment obligation.
Net Income Loss [Abstract]
Numerator:
Non-statutory options.
Non Statutory Options [Member]
Non-Statutory Options
Derivative Liability, Fair Value, Gross Liability, Total
Derivative Fair Value Of Derivative Liability
Success payment liability
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Granted
Milestone expense
Milestone Expense
The amount of expense recognized during the period for achievement of a milestone.
Purchase of non-controlling equity investment
Payments to Acquire Equity Securities, FV-NI
Assets sold for leaseback
The sale price of assets sold to a leasing company for leaseback.
Sale Of Stock Name Of Transaction [Domain]
Sale of Stock
Related Party Transaction [Line Items]
Related Party Transaction [Line Items]
Thereafter
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Plan Name [Domain]
Plan Name
Other comprehensive income (loss)
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent, Total
Other Comprehensive Income Loss Net Of Tax Portion Attributable To Parent
Contingent Consideration Type [Domain]
Share based compensation arrangement by share based payment award weighted average remaining contractual life.
Share Based Compensation Arrangement By Share Based Payment Award Weighted Average Remaining Contractual Life [Abstract]
Weighted average remaining contractual life (years)
Lessee Lease Description [Table]
Lessee Lease Description [Table]
Class Of Stock [Line Items]
Class Of Stock [Line Items]
Components Of Deferred Tax Assets [Abstract]
Deferred tax assets:
Income Tax Authority [Axis]
Income Tax Authority
Depreciation, Total
Depreciation
Depreciation
Depreciation expense
Lessee Operating Lease Term Of Contract
Operating lease term
Valuation Allowance Deferred Tax Asset Change In Amount
Increase in valuation allowance
Effective Income Tax Rate Reconciliation State And Local Income Taxes
State income taxes, net of federal benefit
Issuance of common stock from initial public offering/private placement/At-the-Market offering, net of issuance costs
Value of common stock shares issued
Stock Issued During Period Value New Issues
Liability For Uncertain Tax Positions Current
Uncertain tax positions
Common Stock Issued
Common stock issued.
Open tax year
Open Tax Year
Net cash acquired from Guide
Cash Acquired from Acquisition
Contingent Consideration Liabilities
Business Combinations Policy [Policy Text Block]
Share-based Payment Arrangement, Noncash Expense, Total
Share Based Compensation
Stock-based compensation expense
Prepaid Expense And Other Assets Current
Prepaid expenses and other current assets
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from lease liabilities.
Deferred Tax Assets Leasing Arrangements
Lease liability
Schedule Of Share Based Compensation Stock Options Activity Table [Text Block]
Summary of Option Activity Under Equity Award Plans
Property Plant And Equipment Type [Domain]
Long-Lived Tangible Asset
Related Party Transactions [Abstract]
Amount, before tax, of unrealized gain on investment in debt and equity securities measured at fair value (available-for-sale).
Marketable securities held, Gross Unrealized Gains
Available For Sale Debt Securities and Equity Securities FV-Ni Accumulated Gross Unrealized Gain Before Taxes
Issuance of common stock for success payment liability
Value of stock issued to satisfy success payment obligation.
Stock Issued During Period Value Success Payment Liability
Fair value of equity instruments issued
Business Combination, Consideration Transferred, Equity Interests Issued and Issuable
Equity issuance costs
Deferred Offering Costs
Founder Shareholders.
Founder Shareholders [Member]
Founder Shareholders
Contingent consideration liabilities
Business Combination, Contingent Consideration, Liability, Noncurrent
Contingent consideration liability
Business Combination, Contingent Consideration, Liability
Business Combination, Contingent Consideration, Liability, Total
Proceeds From Issuance Of Preferred Stock And Preference Stock
Proceeds from issuance of Series B Preferred Stock, net
Exercisable as of December 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Product Milestones
Contingent Consideration of Product Liabilities
Contingent Consideration Of Product Liabilities [Member]
Contingent consideration of product liabilities.
Net Cash Provided By Used In Financing Activities
Net cash provided by financing activities
Tabular disclosure of the principal and interest portions of a finance lease.
Summary Of Principal And Interest Portions Table [Text Block]
Summary of Principal and Interest Portions
Operating lease liabilities arising from obtaining ROU assets
Right Of Use Asset Obtained In Exchange For Operating Lease Liability
Operating lease liabilities arising from obtaining right-of-use assets
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Vested
Assets
Total assets
Former Stockholders and Optionholders
Former stockholders and optionholders.
Former Stockholders and Optionholders [Member]
Fair Value Inputs Level2 [Member]
Level 2
Leasehold improvements landlord allowance
The monetary allowance granted by the landlord to a tenant to entice tenant to move into landlords building which will enable the tenant to prepare the leased premises for tenants occupancy.
Leasehold Improvements Landlord Allowance
Leases
Lessee, Operating Leases [Text Block]
Stock Issued During Period Shares Stock Options Exercised
Exercise of common stock options, Shares
Exercised
Type Of Revenue [Extensible List]
Revenue, Product and Service [Extensible List]
Net operating loss carryforwards expiration starting year
Net Operating Loss Carryforwards Expiration Starting Year
The year in which net operating loss carryforwards begin to expire.
Statement [Line Items]
Statement [Line Items]
Total liabilities, redeemable convertible preferred stock, and stockholders' equity
Liabilities And Stockholders Equity
Balance Sheet Location [Domain]
Balance Sheet Location
Property Plant And Equipment [Abstract]
Statement Of Cash Flows [Abstract]
Manufacturing facility, number of square feet
The area of a facility being built for future lease, in square feet.
Area Of Facility Being Built
Payments
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Settlements
2024
Finance Lease Liability Payments Due Year Three
Additional Paid In Capital [Member]
Additional Paid-in Capital
Security12b Title
Title of 12(b) Security
Comprehensive Income Net Of Tax
Comprehensive loss
Summary of Lease Costs Included in Measurement of Lease Liabilities
Tabular disclosure of the lease costs included in the measurement of lease liabilities.
Lease Costs Included In Measurement Of Lease Liabilities [Table Text Block]
Proceeds from equipment financings
Amount of cash inflow from draw down on funds for a finance lease.
Proceeds From Finance Lease
Fair Value Inputs Level3 [Member]
Level 3
Amount of operating loss carryforward that is not subject to expiration.
Operating Loss Carryforward Not Subject To Expiration
Net operating loss carryforwards not subject to expiration
Entity Well Known Seasoned Issuer
Entity Well-known Seasoned Issuer
Operating Loss Carryforwards [Line Items]
Operating Loss Carryforwards [Line Items]
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Award Type
Interest and other income (expense).
Interest And Other Income Expense [Member]
Interest and Other Income (Expense), Net
Interest and Other Income (Expense)
Prepaid expenses and other assets
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Prepaid Expense and Other Assets
Transaction price allocated
Business Combination Transaction Price Allocated [Abstract]
Business combination transaction price allocated.
The year in which specified tax credits begin to expire.
Tax Credits Expiration Starting Year
Tax credits expiration starting year
Issuance of common stock for success payment liability, Shares
Issuance of common stock for success payment liability, Shares
Issuance of common stock for success payment liability, Shares
Number of shares issued to satisfy success payment obligation.
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Sublease area of rented space
The amount of space to be subleased, in square feet.
Sublease Area Of Rented Space
Sharebased Compensation Arrangement By Sharebased Payment Award Expiration Period
Expiration period
Change in fair value
Liabilities, Fair Value Adjustment
2022
Finance Lease Liability Payments Due Next Twelve Months
2023
Finance Lease Liability Payments Due Year Two
Potential aggregate consideration that may be received as part of a collaboration agreement.
Potential total consideration
Potential Consideration
Percentage of common stock purchase price lower of the fair market value
Share Based Compensation Arrangement By Share Based Payment Award Discount From Market Price Offering Date
Common stock offering price discount rate at start of the offering period
Nonvested Restricted Stock Shares Activity Table [Text Block]
Summary of Restricted Stock Activity
Property Plant And Equipment [Text Block]
Schedule of Property and Equipment
Fair Value Inputs Level1 [Member]
Level 1
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
2025
Lessee Operating Lease Liability Payments Due Year Four
Deferred Tax Assets Liabilities Net
Deferred tax assets, net
Plus: residual values
Direct Financing Lease, Residual Value of Leased Asset
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
Change in valuation allowance
Restricted Stock [Member]
Restricted Stock
Unvested Restricted Stock
Total other income (expense)
Nonoperating Income (Expense)
Corporate Debt Securities [Member]
Corporate Notes
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Granted
Obligation to issue common stock value
The value of stock the Company is obligated to issue to the Collaborator if the Company elects to extend the collaboration.
Obligation to Issue Common Stock Value
Entity Current Reporting Status
Entity Current Reporting Status
Collaborative Arrangement Disclosure [Text Block]
Collaboration and License Agreements
Collaboration arrangement, initial term
Collaboration arrangement initial term.
Collaboration Arrangement Initial Term
Probability of Achievement
Measurement Input Probability Of Achievement [Member]
Measurement Input Probability Of Achievement [Member]
Allocated transaction price to each of six performance obligations
Revenue, Remaining Performance Obligation, Amount
Measurement Input Type [Domain]
Measurement Input Type
Entity Voluntary Filers
Entity Voluntary Filers
Scenario [Domain]
Finance lease liability residual values.
Finance Lease Liability Residual Values
Plus: residual values
Money Market Funds [Member]
Money Market Funds
The amount of revenue allocated to each performance obligation.
Revenue remaining for each performance obligations
Revenue Remaining for Each Performance Obligation
Documents Incorporated By Reference [Text Block]
Documents Incorporated by Reference
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Issued
The entire disclosure for licensing arrangements with third parties, which includes, but is not limited to, success payments and milestone payments.
License Agreement Disclosure [Text Block]
License Agreements
Guide Merger Agreement
Merger agreement.
Merger Agreement [Member]
Merger Agreement
Lessee Operating Lease Option To Extend
Operating lease, option to extend
Debt Securities, Available-for-sale [Table]
Earnings Per Share Policy [Text Block]
Net Loss Per Share
Amount of interest income and income (expense) related to nonoperating activities classified as other.
Interest And Other Income Expense Net
Interest and other income (expense), net
Defined Contribution Plan Employer Matching Contribution Percent
Employer matching contribution to 401(k) Plan as a percentage of employee's eligible earnings
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Summary of Stock-based Compensation Expense
Two thousand seventeen stock option and grant plan.
Two Thousand Seventeen Stock Option And Grant Plan [Member]
2017 Plan
Rent payments beginning month and year
The month and year in which the rent payments will begin under an operating lease.
Operating Lease Rent Payments Begin Month And Year
Compensation And Retirement Disclosure [Abstract]
Change in fair value of derivative liabilities
Derivative, Gain (Loss) on Derivative, Net, Total
Derivative Gain Loss On Derivative Net
Change in fair value of derivative liabilities
Computer Equipment [Member]
Computer Equipment
Realized gains or losses recognized on sale or maturity of marketable securities
Marketable Securities, Realized Gain (Loss)
Marketable Securities, Realized Gain (Loss), Total
Accretion of redeemable convertible preferred stock to redemption value
Adjustments to Additional Paid in Capital, Increase in Carrying Amount of Redeemable Preferred Stock
Accumulated Other Comprehensive Income [Member]
Accumulated Other Comprehensive (Loss) Income
Auditor Firm ID
Income Statement Location [Domain]
Income Statement Location
Schedule of change in Fair Value of Liabilities based on Level 3 inputs
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Text Block]
Schedule of Calculation of Estimated Fair Value of Success Payment Liabilities
Auditor Name
Carrying Reported Amount Fair Value Disclosure [Member]
Carrying Amount
Net loss per common share attributable to common stockholders, basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Preferred Stock Shares Authorized
Preferred stock, shares authorized
Exercisable as of December 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Collaboration agreement term of contract
Collaboration Agreement Term of Contract
Collaboration agreement term of contract.
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
Unrecognized Tax Benefits Income Tax Penalties And Interest Expense
Interest or penalties for unrecognized tax benefits since inception
Minimum [Member]
Minimum
Minimum
The fair value of shares received as part of a collaboration and license agreement.
Collaboration license agreement fair value of shares received
Collaboration License Agreement Fair Value of Shares Received
Laboratory space.
Laboratory Space [Member]
Laboratory Space
Fair Value Measurement Frequency [Domain]
Measurement Frequency
Lessee, operating lease, security deposit
Security Deposit
Stock Issued During Period Value Stock Options Exercised
Exercise of common stock options
Increase in operating lease right-of-use assets
Increase (decrease) in operating lease right of use asset.
Increase Decrease In Operating Lease Right Of Use Asset
Finance lease liability payments.
Finance Lease Liability Payments [Table]
Finance Lease Liability Payments [Table]
Finance Lease Liability Noncurrent
Long-term equipment financing liability
Guarantee Obligations Current Carrying Value
Claims outstanding
Other Noncurrent Assets [Member]
Other Assets
Verve.
Verve [Member]
Verve
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Total Fair Value
Aggregate fair value of restricted shares vested
Lessee Finance Lease Term Of Contract1
Financing obligations, leased back equipment term of contract
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Issued
Issuance of restricted common stock
Measurement input fair value of common stock.
Measurement Input Fair Value Of Common Stock [Member]
Fair Value of Common Stock
Operating Lease Liabilities Payments Due [Abstract]
Organization Consolidation And Presentation Of Financial Statements Disclosure [Text Block]
Nature of the Business and Basis of Presentation
Laboratory equipment and office furniture.
Laboratory Equipment And Office Furniture [Member]
Laboratory Equipment and Office Furniture
Schedule of Business Acquisitions, by Acquisition [Table]
Document Annual Report
Document Annual Report
Number of shares purchased under equity method
Number of shares purchased under equity method.
Number of Shares Purchased Under Equity Method
Deferred Tax Assets, Valuation Allowance, Total
Deferred Tax Assets Valuation Allowance
Less: valuation allowance
Broad Institute
Broad Institute [Member]
Broad Institute.
Net Cash Provided By Used In Financing Activities [Abstract]
Financing activities
Entity Filer Category
Entity Filer Category
Value of stock issued during the period upon vesting of restricted common stock.
Stock Issued During Period Value Vesting Of Restricted Common Stock
Vesting of restricted common stock
Income Tax Policy [Text Block]
Income Taxes
Document Fiscal Year Focus
Document Fiscal Year Focus
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Corporate Equity Securities
Equity Method Investments [Policy Text Block]
The amount of liability incurred for success payments.
Success Payment Liability
Success payments liability
Construction In Progress [Member]
Construction in Process
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Weighted-average grant date fair value per share of stock options granted
Derivative Liabilities Current
Derivative liabilities
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Total
Retained Earnings Accumulated Deficit
Accumulated deficit
Accumulated deficit
Value of stock issued during the period related to a license agreement.
Issuance Of Common Stock Value Related To License Agreement
Issuance of common stock related to license agreement
Income Tax Disclosure [Text Block]
Income Taxes
Fair Value Disclosures [Abstract]
Property Plant And Equipment Disclosure [Text Block]
Property and Equipment, Net
Assigned to Pfizer
Assigned to Pfizer [Member]
Assigned to Pfizer.
Short Term Lease Cost
Short-term lease costs
Jeffries LLC Sales Agreement and Amended Sales Agreement
Jeffries LLC Sales Agreement and Amended Sales Agreement.
Jeffries LLC Sales Agreement And Amended Sales Agreement [Member]
Maximum [Member]
Maximum
Entity Central Index Key
Entity Central Index Key
Assembled Workforce
Assembled Workforce.
Assembled Workforce [Member]
Cash, Cash Equivalents, and Restricted Cash
Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy
Business Acquisition Acquiree [Domain]
Business Acquisition, Acquiree
Summary of Lease Term and Discount Rate
Tabular disclosure of the lease term and discount rate for an operating lease.
Operating Lease Term And Discount Rate [Table Text Block]
The commission rate the Company agreed to pay for all shares sold under a Sales Agreement, as a percentage of gross sales proceeds.
Commission Rate
Commission rate
Payables And Accruals [Abstract]
Measurement Input Type [Axis]
Measurement Input Type
Issuance of common stock to acquire Guide
Value of shares issued for upfront payment of acquisition
Stock Issued During Period, Value, Acquisitions
Scientific consulting and other expenses.
Scientific Consulting And Other Expenses [Member]
Scientific Consulting and Other Expenses
Amount of contingent consideration liability for technology and product milestones incurred by the acquirer.
Business Combination Consideration Transferred Technology And Product Contingent Consideration Liabilities
Business combination liability for milestones at fair value
Technology and product contingent consideration liabilities
Entity Tax Identification Number
Entity Tax Identification Number
Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to acquisition related in process research and development expenses.
IPR&D Guide Acquisition
Effective Income Tax Rate Reconciliation In Process Research And Development Acquisition
Equity Component [Domain]
Equity Component
Editas License Agreement.
Editas License Agreement [Member]
Editas License Agreement
Preferred Stock Par Or Stated Value Per Share
Preferred stock, par or stated value per share
Expected volatility
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Derivative Liability Measurement Input
Success payment liability measurement input
Property Plant And Equipment Policy [Text Block]
Property and Equipment
Reverse stock split ratio
Stockholders' Equity Note, Stock Split, Conversion Ratio
Two thousand nineteen equity incentive plan.
Two Thousand Nineteen Equity Incentive Plan [Member]
2019 Plan
Prime Agreement
Prime Agreement [Member]
Income Tax Authority [Domain]
Income Tax Authority
Consolidation Variable Interest Entity Policy
Variable Interest Entities
Employees, officers, founders and consultants.
Employees Officers Founders And Consultants [Member]
Employees, Officers, Founders and Consultants
Maximum amount allowed to purchase common stock using payroll deduction
The maximum annual amount of funds that employees can contribute through payroll deductions to purchase shares as part of share based compensation plan.
Share Based Compensation Arrangement By Share Based Payment Award Payroll Deduction Yearly Limit Amount
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Unrecognized compensation cost, cost to recognize over a weighted-average period
Amount of expenses incurred but not yet paid nor invoiced, and liabilities classified as other, payable within one year or the normal operating cycle, if longer.
Accrued Expenses And Other Current Liabilities
Accrued expenses and other current liabilities
Total
Temporary equity, issuance cost
Temporary Equity Issuance Costs
Costs incurred in a temporary equity issuance transaction.
Research and development expense offset amount
Research and development expense offset amount.
Research and Development Expense Offset Amount
Tabular disclosure of the change in fair value of the success payment liability arising from a licensing agreement.
Schedule Of Change In Fair Value Of Success Payment Liability Table [Text Block]
Schedule of Change in Fair Value of Success Payment Liability
The aggregate amount of potential fee for additional option rights.
Option rights aggregate potential additional consideration
Option Rights Aggregate Potential Additional Consideration
October 2020 Public offering.
October Two Thousand Twenty Public Offering [Member]
October 2020 Public Offering
Related Party Transaction Other Revenues From Transactions With Related Party
Income from related party
In-Process Research and Development
In Process Research and Development [Member]
Change In Accounting Principle Accounting Standards Update Adoption Date
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Leasehold Improvements [Member]
Leasehold Improvements
Number of shares available for future issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Authorized
Maximum number of shares for future issuance
Two thousand nineteen employee stock purchase plan.
Two Thousand Nineteen Employee Stock Purchase Plan [Member]
2019 Employee Stock Purchase Plan
Statement [Table]
Statement [Table]
Operating Lease Weighted Average Remaining Lease Term1
Weighted-average remaining lease term (years)
Success payment amount due
Success Payment Amount Due
The amount of success payment due as part of a license agreement.
Entity File Number
Entity File Number
Nature of the business and basis of presentation.
Nature Of Business And Basis Of Presentation [Line Items]
Nature Of Business And Basis Of Presentation [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Lessee Lease Description [Line Items]
Lessee Lease Description [Line Items]
Increase Decrease In Other Noncurrent Assets
Other long-term assets
Retained Earnings [Member]
Accumulated Deficit
Public offering price per share
Shares Issued, Price Per Share
Accounting Standards Update [Domain]
Accounting Standards Update [Axis]
Amount of transactions costs incurred by the acquirer.
Business Acquisition Cost Of Acquired Entity Transaction Cost
Transaction costs
License revenue
License and collaboration revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Payment of initial and follow-on equity offering costs
Payments Of Stock Issuance Costs
Payment of initial and follow-on public offering costs
Increase (Decrease) in Accounts Payable, Total
Increase Decrease In Accounts Payable
Accounts payable
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Liabilities Current [Abstract]
Current liabilities:
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Stock Option and Grant Plan
Subsequent Event [Member]
Subsequent Event
Increase in operating lease liability
Increase (decrease) in operating lease liabilities.
Increase Decrease In Operating Lease Liabilities
Operating lease liabilities
Finance Lease Liability Current
Current portion of equipment financing liability
Total operating lease liabilities
Lease liability
Operating Lease, Liability, Total
Operating Lease Liability
Collaboration agreement aggregate transaction price
The aggregate transaction price of a collaboration agreement.
Collaboration Agreement Aggregate Transaction Price
Common Stock [Member]
Common Stock
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Total
Property Plant And Equipment Gross
Total property and equipment
Accrued Professional Fees Current
Professional fees
Amount of investment in debt and equity securities measured at fair value, classified as available-for-sale.
Marketable securities
Available For Sale Debt Securities and Equity Securities FV-Ni Current
Entity Public Float
Entity Public Float
Cover [Abstract]
Credit Facility [Domain]
Revenue remaining performance obligation, expected timing of satisfaction, period
Revenue, Remaining For Each Performance Obligation, Expected Timing of Satisfaction, Period
Revenue, remaining for each performance obligation, expected timing of satisfaction, period.
Unvested as of December 31, 2021
Unvested as of December 31, 2020
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Fair Value By Asset Class [Axis]
Asset Class
Deferred Tax Assets Tax Credit Carryforwards Research
Research and development tax credits
Related Party Transaction [Domain]
Related Party Transaction
Temporary Equity Shares Outstanding
Redeemable convertible preferred stock, Ending Balance, Shares
Redeemable convertible preferred stock, Beginning Balance, Shares
Preferred stock outstanding
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Table]
Statement Of Stockholders Equity [Abstract]
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Number Of Operating Segments
Number of operating segment
Rental payment over term of sublease
The amount of rental payments the Company is expected to receive over the term of a sublease.
Rental Payment Over Term of Sublease
Ending Balance
Beginning Balance
Beginning Balance
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value
Aggregate gross proceeds of shares authorized under ATM sales agreement
Amount of shares authorized to be issued under a stock issuance program.
Stock Issuance Program Authorized Amount
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Asset Acquisitions
Disclosure of accounting policy for asset acquisitions, both as part of a business combination and not as part of a business combination.
Asset Acquisitions [Policy Text Block]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Fair Value Of Financial Instruments Policy
Fair Value of Financial Instruments
2025
Finance Lease Liability Payments Due Year Four
Collaboration agreement transaction price to each of six performance obligations
Collaboration Agreement Transaction Price for Each Performance Obligations
Collaboration agreement transaction price for each performance obligations.
Derivative Liability [Abstract]
Cash, Cash Equivalents, and Short-term Investments, Total
Cash Cash Equivalents And Short Term Investments
Cash, cash equivalents, and marketable securities
Property Plant And Equipment By Type [Axis]
Long-Lived Tangible Asset
Other
Other Accrued Liabilities, Current
Document Transition Report
Document Transition Report
Proceeds From Stock Options Exercised
Proceeds from exercise of stock options
Amortized cost of investment in debt and equity securities measured at fair value (available-for-sale).
Marketable securities held, Amortized Cost
Available For Sale Debt Securities and Equity Securities FV-Ni Amortized Cost Basis
Letter of Credit
Letter of Credit [Member]
Lessee Operating Lease Renewal Term
Operating lease, option to extend term
Research and development expense
Research and Development Expense, Total
Research and development
Schedule of property and equipment, estimated useful life.
Schedule Of Property And Equipment Estimated Useful Life Table [Text Block]
Estimated Useful Life of Property and Equipment
Long-term portion of deferred revenue
Contract with Customer, Liability, Noncurrent
Weighted average number of common shares, diluted
Weighted-average common shares used in net loss per share attributable to common stockholders, diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Bio Palette License Agreement.
Bio Palette License Agreement [Member]
Bio Palette License Agreement
Issuance of common stock to acquire Guide, Shares
Stock Issued During Period, Shares, Acquisitions
Allocated Share Based Compensation Expense
Stock-based compensation expense
Other Payments
Other Payments [Member]
Other Payments.
Amortization of investment discount (premium)
Investment Income, Net, Amortization of Discount and Premium, Total
Investment Income Net Amortization Of Discount And Premium
Change in fair value
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease)
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Period Increase (Decrease), Total
Collaboration receivable
Collaboration receivable
The increase (decrease) during the reporting period in amount due within one year (or one business cycle) as part of a collaboration agreement.
Increase Decrease in Collaboration Receivable
Maturities of marketable securities
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-sale
Statement Of Financial Position [Abstract]
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Expected dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Vested
Aggregate milestone amount
Aggregate Milestone Amount
The aggregate amount the Company is obligated to pay upon achievement of specified milestones.
Discount Rate
Measurement Input, Discount Rate [Member]
Depreciation and amortization
Depreciation, Depletion and Amortization
Depreciation, Depletion and Amortization, Total
Accrued expenses and other
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities
Lease Contractual Term [Axis]
Lease Contractual Term
Product Development and Regulatory Approval
Product Development and Regulatory Approval [Member]
Product Development and Regulatory Approval.
2026
Lessee, Operating Lease, Liability, to be Paid, Year Five
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
Federal statutory rate
Stockholders' equity:
Stockholders Equity [Abstract]
Patent Costs
Goodwill and Intangible Assets, Intangible Assets, Policy [Policy Text Block]
Lease Contractual Term [Domain]
Lease Contractual Term
Compensation Related Costs Policy [Text Block]
Stock-Based Compensation
Computer equipment and software.
Computer Equipment And Software [Member]
Computer Equipment and Software
Schedule Of Earnings Per Share Basic And Diluted Table [Text Block]
Summary of Computation of Basic and Diluted Net Loss per Share Attributable to Common Stockholders
Weighted-average exercise price of stock options
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Exercised
Increase Decrease In Operating Capital [Abstract]
Changes in operating assets and liabilities:
2024
Lessee Operating Lease Liability Payments Due Year Three
Entity Common Stock Shares Outstanding
Entity Common Stock, Shares Outstanding
Common Stock Capital Shares Reserved For Future Issuance
Number of shares reserved for future issuance
Finance lease liability payments.
Finance Lease Liability Payments [Line Items]
Finance Lease Liability Payments [Line Items]
Fair Value By Measurement Frequency [Axis]
Measurement Frequency
Award Type [Axis]
Award Type
Entity Shell Company
Entity Shell Company
Debt Securities, Available-for-sale [Line Items]
Liabilities and stockholders' equity
Liabilities And Stockholders Equity [Abstract]
Liabilities, redeemable convertible preferred stock, and stockholders’ equity (deficit)
Income Tax Authority, Name [Axis]
Icfr Auditor Attestation Flag
ICFR Auditor Attestation Flag
Consideration of Technology Liabilities
Technology Milestones
Contingent Consideration Of Technology Liabilities [Member]
Contingent consideration of technology liabilities.
Entity Incorporation State Country Code
Entity Incorporation, State or Country Code
Upfront payment received under term of agreement
Upfront Payment Received Under Term of Agreement
The amount of upfront payment received under the terms of an agreement.
Earnings Per Share [Text Block]
Net Loss per Share Attributable to Common Stockholders
Counterparty Name [Domain]
Harvard
Harvard license agreement.
Harvard License Agreement [Member]
Harvard
Amount of expenses incurred but not yet paid for sub-license fees, payable within one year or the normal operating cycle, if longer.
Accrued sub-license fees
Accrued Sub License Fees Current
Fair Value Disclosure Item Amounts [Domain]
Fair Value Measurement
Commencement of first phase of lease in October 2020.
Commencement Of First Phase Of Lease In October Twenty Twenty [Member]
First Phase of Lease in October 2020
Deferred Tax Liabilities Leasing Arrangements
ROU asset
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested [Roll Forward]
Shares
Amendment Flag
Amendment Flag
Upfront fee receivable upon signing contract
The amount of upfront fee receivable upon signing of a collaboration agreement.
Schedule Of Stock By Class [Table]
Schedule Of Stock By Class [Table]
Product Or Service [Axis]
Product and Service
Conversion Of Stock Amount Converted1
Conversion of redeemable convertible preferred stock to common stock upon closing of the initial public offering
Repayment of equipment financings
Finance Lease Principal Payments
Paydown of principal
Collaborative arrangement rights and obligations, description
Collaborative Arrangement, Rights and Obligations
Deferred revenue
Increase (Decrease) in Contract with Customer, Liability
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash And Cash Equivalents At Carrying Value
Cash and cash equivalents
Title Of Individual With Relationship To Entity [Domain]
Title of Individual
Number of common stock received
The number of shares of stock received as part of a collaboration and license agreement.
Collaboration License Agreement Shares Received
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Effective Income Tax Rate Reconciliation Nondeductible Expense
Nondeductible/ nontaxable permanent items
Guarantees Indemnifications And Warranties Policies
Guarantees and Indemnifications
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Unrecognized compensation cost related to unvested stock options
Deferred Tax Assets Derivative Instruments
Derivative liabilities
Fair Value Measurements Recurring [Member]
Recurring
Increase Decrease In Accrued Liabilities And Other Operating Liabilities
Accrued expenses and other liabilities
Equity securities, Amortized Cost
Equity securities, Fair Value
Equity Securities, FV-NI, Cost
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from amortization.
Deferred Tax Assets Amortization
Amortization
Corporate Equity Securities
Corporate equity securities.
Corporate Equity Securities [Member]
Regulatory
Regulatory [Member]
Regulatory
Tax Period [Domain]
Antidilutive Securities Name [Domain]
Antidilutive Securities, Name
Property Plant And Equipment [Line Items]
Property Plant And Equipment [Line Items]
Other Assets, Noncurrent, Total
Other Assets Noncurrent
Other assets
ESPP
Employee Stock [Member]
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Segment Geographical [Domain]
Geographical
Exercisable as of December 31, 2021
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Stock sold during period shares, new issues
Number of new shares sold, but not necessarily issued, during the period.
Stock Sold During Period Shares, New Issues
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Finite-Lived Intangible Assets, Major Class Name [Domain]
Other Operating Income Expense.
Other Operating Income Expense [Abstract]
Other income (expense):
Fair Value Disclosures [Text Block]
Fair Value of Financial Instruments
Success Payment Liabilities
Success Payment Liabilities [Member]
Success payment liabilities.
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Share Based Awards Other Than Options
Unrecognized stock-based compensation expense, expected to vest
Proceeds from issuance of common shares, net of underwriting discount and commissions
Proceeds from Issuance of Common Stock