United States securities and exchange commission logo July 20, 2023 Terry-Ann Burrell Chief Financial Officer and Treasurer Beam Therapeutics Inc. 238 Main Street Cambridge, MA 02142 Re: Beam Therapeutics Inc. Form 10-K for the Year Ended December 31, 2022 Filed February 28, 2023 File No. 001-39208 Dear Terry-Ann Burrell: We have limited our review of your filing to the financial statements and related disclosures and have the following comment. In our comment, we may ask you to provide us with information so we may better understand your disclosure. Please respond to the comment within ten business days by providing the requested information or advise us as soon as possible when you will respond. If you do not believe our comment applies to your facts and circumstances, please tell us why in your response. After reviewing your response to the comment, we may have additional comments. Form 10-K for the Year Ended December 31, 2022 Notes to Consolidated Financial Statements 8. Equity method investment Orbital, page F-26 1. Please address the following as it relates to your equity method investment in Orbital Therapeutics: Reconcile your disclosure that you received a 31.5% fully diluted equity interest in Orbital at the time of your initial investment and that of December 31, 2022 you hold 95.8% of its outstanding common stock with your risk factor disclosure on page 77 whereby you state that you hold a "minority interest" in Orbital. Provide us with your analysis under ASC 810 supporting your determination that you are not the primary beneficiary of Orbital. As part of your response, identify the activities of Orbital that most significantly impact its economic performance and Terry-Ann Burrell Beam Therapeutics Inc. July 20, 2023 Page 2 explain how you determined that you do not have the power to direct such activities and therefore do not hold a controlling financial interest. Explain how the interim management services you are providing Orbital in addition to your board representation factored into your analysis. To the extent that the power is shared among the various variable interest holders, clarify whether there is a tie-breaking mechanism in place with respect to key decision making. In closing, we remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. You may contact Mary Mast at (202) 551-3613 or Angela Connell at (202) 551- 3426 with any questions. FirstName LastNameTerry-Ann Burrell Sincerely, Comapany NameBeam Therapeutics Inc. Division of Corporation Finance July 20, 2023 Page 2 Office of Life Sciences FirstName LastName