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Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to Be Held on June 8, 2022 Your Vote Counts! BEAM THERAPEUTICS INC. 2022 Annual Meeting June 8, 2022 11:30 AM EDT Virtual Meeting Site: BEAM THERAPEUTICS INC. 238 MAIN STREET CAMBRIDGE, MA 02142 D77963-P67615 You invested in BEAM THERAPEUTICS INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the stockholder meeting to be held on June 8, 2022. Get informed before you vote View the Notice and Proxy Statement and 2021 Annual Report online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 25, 2022. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit, (2) call 1-800-579-1639 or (3) send an email to If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. To view the proxy materials and to vote, visit Control # Vote Virtually at the Meeting* Vote on June 8, 2022 11:30 AM, EDT Visit: Smartphone users Point your camera here and vote without entering a control number Vote in Advance of the Meeting Vote by June 7, 2022 11:59 PM ET Visit *Please check the meeting materials for any special requirements for meeting attendance. V1.1 


1. Election of the following nominees as Class II Directors for three-year terms ending at our annual meeting of stockholders to be held in 2025. Nominees: 1a. Mark Fishman, M.D. For 1b. Carole Ho, M.D. For 1c. Kathleen Walsh For 2. Ratify the appointment of Deloitte & Touche LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2022. For 3. Approve, on an advisory basis, the compensation of our named executive officers. For 4. Indicate, on an advisory basis, the preferred frequency of advisory votes on executive compensation. Every Year Note: The proxies are authorized to vote in their discretion upon such other business as may properly come before the Annual Meeting or any continuation, postponement, or adjournment thereof. Vote at THIS IS NOT A VOTABLE BALLOT This is an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. Please follow the instructions on the reverse side to vote these important matters. Board Recommends Voting Items Prefer to receive an email instead? While voting on, be sure to click “Sign up for E-delivery”. D77964-P67615